Evaluation of the efficiency and safety of topical application of the bacteriophage-containing gels Fagogin and Fagoderm for the prevention of wound complications in puerperas


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Abstract

Objective: to evaluate the efficacy and safety of complex bacteriophage-containing agents on a gel basis (the gels Fagogin and Fagoderm) for the prevention of wound complications in the postpartum period. Material and methods. Fagogin and Fagoderm contain a set of 40 bacteriophages that suppress the growth of opportunistic pathogenic microorganisms (OPMs) found on the vaginal mucosa and skin. The investigation enrolled 141 patients, including 66 (Fagogin users) after spontaneous labor and 75 (Fagoderm users) after cesarean section; the sutures were treated with the prophylactic agent Fagogin in 18 of them and with the prophylactic agent Fagoderm in 25; 98 patients formed a control group (suture treatment with potassium permanganate). Results. The efficacy of Fagogin and Fagoderm is confirmed by the absence of cases of wound infections during wound treatment with the test agents. There were no statistically significant differences in the assessment of subjective sensations in the women of the Fagogin and Fagoderm groups and in those of the control group. Fagogin and Fagoderm were tested for microbiological efficacy on 161 OPM strains with different antibiotic susceptibility, which were isolated from vaginal discharge in reproductive-aged women. The prophylactic agents, including those against antibiotic-resistant microorganisms, were shown to have a high antimicrobial activity. Conclusion. The findings confirm the efficacy and safety of Fagogin and Fagoderm for the prevention of infectious complications in puerperas.

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About the authors

Tatiana V. Priputnevich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: priput1@gmail.com
Head of the Department of microbiology, clinical pharmacology and epidemiology

Lyudmila A. Lyubasovskaya

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: labmik@yandex.ru
Head of the Unit of clinical pharmacology, Department of microbiology, clinical pharmacology and epidemiology

Alla A. Ignatyeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: Ignateva-alla@mail.ru
Head of II Department of Obstetrics Phisiology

Tamara E. Karapetyan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: tomamed02@mail.ru
High scientific researches of Obstetric department

Valeriy V. Chubarov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: v_chubarov@oparina4.ru
Head of Department of epidemiology, Department of microbiology, clinical pharmacology and epidemiology

Alexander Y. Zurabov

Research and Production Centre “MicroWorld” Ltd

Email: azurabov@micro-world.ru
CEO

Valentina M. Popova

Research and Production Centre “MicroWorld” Ltd

Email: popovavm9@yandex.ru
Deputy of CEO

E. L Zhilenkov

Research and Production Centre “MicroWorld” Ltd

Email: zhilenkovevgeny@gmail.com
Deputy of CEO

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