Small non-coding RNAs and their potential role in assessing the fertility of a married couple in assisted reproductive technology programs


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Abstract

The authors carried out a systematic analysis of scientific data on the impact of small non-coding RNAs on gametogenesis, embryogenesis, and outcomes of in vitro fertilization programs. Despite the fact that there is a rapid development of assisted reproductive technologies, the rate of successful embryo implantations in the uterine cavity is still at a fairly low level. Therefore, at the moment, scientists are actively searching for the ideal biomarker that determines the quality of gametes and their potential in the formation of a high-quality embryo with the further development of physiological pregnancy. An analysis of the data available in the literature has led to the conclusion that the investigation of small non-coding RNAs with the aim of assessing the fertility of a married couple is extremely promising, relevant, and in tune with the times and will be able to increase the effectiveness of in vitro fertilization programs.

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About the authors

M. A Shamina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mariashamina@mail.ru

A. V Timofeeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: avtimofeeva28@gmail.com

E. A Kalinina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru

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