Expression of vitamin d and its receptors in the villous chorion in missed miscarriage


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Vitamin D receptors are known to be found in 36 human tissues, including in the ovarian tissue, endometrium, fallopian tubes, decidua, and placenta of women. In the early stages, trophoblast simultaneously produces and responds to vitamin D that has a local anti-inflammatory effect and induces decidual tissue growth for a successful pregnancy. Objective. To investigate the expression of vitamin D and its receptor in the villous chorion in non-developing and physiological pregnancy. Materials and methods. Sixty-four villous chorion samples divided into 2 groups: 1) 32 from women with missed miscarriage; 2) 32 from those who had undergone medical abortion, were examined. The inclusion criteria were abortion material from women at 6-12 weeks’ gestation, singleton pregnancy, and normal fetal karyotype. Results. The trophoblast and stroma of the chorionic villi showed the uniform distribution of the expression of vitamin D and its receptors. In missed miscarriage, the relative area of the expression of vitamin D and its receptor was statistically smaller than that in Group 2 (10.3%, 15.4% (p < 0.01) and 35.9+1.8; 56.1+2.4 (p < 0.01), respectively). Conclusion. In missed miscarriage, the expression of vitamin D and its receptor is lower.

Full Text

Restricted Access

About the authors

O. N Bespalova

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: shiggerra@mail.ru

M. O Bakleicheva

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

I. V Kovaleva

Skandinaviya (Scandinavia) Clinic

G. Kh Tolibova

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

T. G Tral

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

I. Yu Kogan

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

References

  1. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности: руководство для практикующих врачей. М.; 2011.
  2. Коган И.Ю., Гзгзян А.М., Лесик Е.А. Протоколы стимуляции яичников в циклах ЭКО, руководство для врачей. 2-е изд. М.; 2018.
  3. Palacios C., Gonzalez L. Is vitamin D. deficiency a major global public health problem? J. Steroid BiochemMol Biol. 2014;144(Pt A):138-45. doi: 10.1016/j. jsbmb.2013.11.003
  4. Прилепская В.Н., Короткова Н.А. Применение витаминно-минеральных комплексов при подготовке к зачатию, во время беременности и после родов. Эффективная фармакотерапия. 2013; 51: 24-29.
  5. WHO recommendations on antenatal care for a positive pregnancy experience, 2016.
  6. Gongalves D.R., Braga A., Braga J., Marinho A. Recurrent pregnancy loss and vitamin D: A review of the literature. Am J. Reprod Immunol. 2018; 80(5): e13022. doi: 10.1111/aji.13022.
  7. Holmes V.A., Barnes M.S.,Alexander H.D., McFaul P., Wallace J.M.W. Vitamin D. deficiency and insufficiency in pregnant women: a longitudinal study. Br J. Nutr. 2009; 102(6): 876-81. doi: 10.1017/S0007114509297236
  8. Karras S.N., Wagner C.L., Castracane V.D. Understanding vitamin D. metabolism in pregnancy: from physiology to pathophysiology and clinical outcomes. Metabolism. 2018; 86: 112-23. doi: 10.1016/j.metabol. 2017.10.001
  9. Ganguly A., Tamblyn J.A., Finn-Sell S., Chan S.Y., Westwood M., Gupta J., et al. Vitamin D., the placenta and early pregnancy: effects on tro-phoblast function. J. Endocrinol. 2018; 236(2): R93-R103. doi: 10.1530/ JOE-17-0491
  10. Norman A.W. From vitamin D. to hormone D: fundamentals of the vitamin D. endocrine system essential for good health. Am J. ClinNutr. 2008; 88(2): 491S-499S. doi: 10.1093/ajcn/88.2.491S
  11. Bakleicheva M., Kovaleva I., Bespalova O., Tolibova G., Tral T. The deficiency of Vitamin D. with threatening miscarriage. The 3rd World Congress on Recurrent Pregnancy Loss (WCRPL 2018). Abstr. June 27-29, 2018, Madrid, Spain.
  12. Bikle D. Nonclassic actions of vitamin D. J. Clin Endocrinol Metab. 2009; 94(1): 26-34. doi: 10.1210/jc.2008-1454
  13. Palacios C., Gonzalez L. Is vitamin D. deficiency a major global public health problem? J. Steroid BiochemMol Biol. 2014; 144Pt A:138-45. doi: 10.1016/ j.jsbmb.2013.11.003
  14. Баклейчева М.О., Ковалева И.В., Беспалова О.Н., Коган И.Ю. Влияние витамина D. на репродуктивное здоровье женщины. Журнал акушерства и женских болезней. 2018; 67(3): 4-19. doi: 10.17816/JOWD6734-19
  15. Saraf R., Morton S.M.B., Camargo C.A., Grant C.C. Global summary of maternal and newborn vitamin D. status - a systematic review. Matern Child Nutr. 2016; 12(4): 647-68. doi: 10.1111/mcn.12210
  16. Bakleicheva M., Kovaleva I., Bespalova O., Iyvashchenko T., Tolibova G.Kh., Tral T.G. The main reasons of threatening miscarriage between women with the vitamin D. deficiency XXVI European Congress Perinatal Medicine ECPM Congress 2018. Abstract book [electronic version]. 2018; 350.
  17. Aghajafari F., Nagulesapillai T., Ronksley P.E., Tough S.C., O’Beirne M., Rabi D.M. Association between maternal serum 25-hydroxyvitamin D. level and pregnancy and neonatal outcomes: systematic review and metaanalysis of observational studies. BMJ. 2013; 346: f1169-f1169. doi: 10.1136/ bmj.f1169
  18. Theodoratou E., Tzoulaki I., Zgaga L., Ioannidis J.P.A. Vitamin D. and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomisedtrials.BMJ. 2014; 348: g2035-g2035. doi: 10.1136/bmj.g2035
  19. De-Regil L.M., Palacios C., Lombardo L.K., Pena-Rosas J.P. Vitamin D. supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016; (1): CD008873.doi: 10.1002/14651858. CD008873.pub3
  20. Merewood A., Mehta S.D., Chen T.C., Bauchner H., Holick M.F. Association between vitamin D. deficiency and primary cesarean section. J. Clin Endocrinol Metab. 2009; 94(3): 940-5. doi: 10.1210/jc.2008-1217
  21. Bodnar L.M., Krohn M.A., Simhan H.N. Maternal vitamin D. deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J. Nutr. 2009;139(6):1157-61. doi: 10.3945/jn.108.103168
  22. Zehnder D., Evans K.N., Kilby M.D., Bulmer J.N., Innes B.A., Stewart P.M., Hewison M. The on-togeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua. Am J. Pathol. 2002; 161(1):105-14. doi: 10.1016/s0002-9440(10)64162-4
  23. Gray T.K., Lester G.E., Lorenc R.S. Evidence for extrarenal 1-hydroxylation of 25-hydroxy vitamin D3 in pregnancy. Science. 1979; 204:1311-13. doi: 10.1126/science.451538
  24. Adams J.S., Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008; 4(2): 80-90. doi: 10.1038/ncpendmet0716
  25. Du H., Daftary G.S., Lalwani S.I., Taylor H.S. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Mol Endocrinol. 2005; 19(9): 2222-33. https://doi.org/10.1210/ me.2004-0336
  26. Bodnar L.M., Krohn M.A., Simhan H.N. Maternal vitamin D. deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J. Nutr. 2009; 139(6): 1157-61. doi: 10.3945/jn.108.103168
  27. Li N., Wu H.M., Hang F., Zhang Y.S., Li M.J. Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D. and VDR at the fetal-maternal interface. Braz J. Med Biol Res. 2017; 50(11): e6527. doi: 10.1590/1414-431X20176527

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies