MicroRNA regulation in the genesis of fetal growth restriction


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Abstract

MicroRNA is a class of short non-coding RNAs that carry out epigenetic regulation of many biological processes, including the course of pregnancy. More than 500 microRNAs associated with the formation and functioning of the placenta are presently known. The expression level of these microRNAs may be an indicator of placental changes during pregnancy. A number of placenta-specific microRNAs detected in maternal plasma can be regarded as potential non-invasive markers of maternal and fetal health. The data available in the modern scientific literature on changes in the expression of placenta-specific microRNAs circulating in the plasma of a pregnant woman with fetal growth restriction are analyzed. MicroRNAs can play an important, but currently not fully investigated role in the initiation of gestational complications. The use of microRNAs in the prediction and treatment of diseases and pregnancy complications is a promising area that requires further investigation.

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About the authors

Ekaterina A. Zabanova

Rostov State Medical University

Email: rock-fe@mail.ru

Natalia B. Kuznetsova

Rostov State Medical University

Email: lauranb@inbox.ru

T. P Skurat

Southern Federal University

Email: tshkurat@sfedu.ru
Tatiana P.

E. V Butenko

Southern Federal University

Email: evbutenko@sfedu.ru
Elena V.

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