Molecular genetic deviations and obstetric pathology


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Abstract

The paper reviews international researches in the role of various gene networks in the development of obstetric pathology. It considers not only the most studied hemostatic system and folate metabolism genes, but also renin-angiotensin-aldosterone system, detoxification system, and immune response ones and genes that regulate the function of the endothelium. In addition, an update on genome-wide studies investigating a genetic predisposition to pregnancy complications is analyzed.

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About the authors

Vladislav V. Kovalev

Ural State Medical University Ministry of Health of Russia

Email: wkovalev55@gmail.com
MD, prof., USMU, Department of Obstetrics and Gynecology of faculty of postgraduate education 620109 Russia, Ekaterinburg, Repina str., 3

Elena V. Kudryavtseva

Ural State Medical University Ministry of Health of Russia

Email: elenavladpopova@yandex.ru
PhD., assotiated professor, USMU, Department of Obstetrics and Gynecology of faculty of postgraduate education 620109 Russia, Ekaterinburg, Repina str., 3

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