Present views on molecular mechanisms of formation of fetal growth restriction


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Abstract

The authors carried out a systematic analysis of the data given in the modern scientific literature on the molecular mechanisms of the formation of fetal growth restriction and their significance in obstetrics. The intrauterine environment can potentially affect biological activity in the fetus and lead to impaired growth and the development of long-term complications. The mechanisms underlying placental insufficiency, JAK-STAT signaling pathway, and the growth hormone-insulin-like growth factor-1 axis are considered. The paper gives data on the epigenetic regulation of these mechanisms and the importance of their further study in order to elaborate new therapeutic approaches in the future.

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About the authors

Z. V Khachatryan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: z.v.khachatryan@gmail.com
postgraduate student 117997, Moscow, Ac. Oparina, 4 str. Tel.: +7-909-656-24-56

N. E Kan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
PhD, MD, professor 117997, Moscow, Ac. Oparina, 4 str. Tel.: +7-909-656-24-56

N. P Makarova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru
Doctor of Biological Sciences, leading researcher of IVF Department 117997, Moscow, Ac. Oparina, 4 str. Tel.: +7-909-656-24-56

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