The influence of immunosuppressive therapy during pregnancy on the immune system of the mother and the newborn
- Authors: Vanko L.V1, Zubkov V.V1, Krechetova L.V1, Makieva M.I1, Baybarina E.N1, Shatalova E.A1, Zhukova A.C1, Klimenchenko N.I1, Shmakov R.G1
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Affiliations:
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
- Issue: No 11 (2019)
- Pages: 113-121
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248646
- DOI: https://doi.org/10.18565/aig.2019.11.113-121
- ID: 248646
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Abstract
Aim. The comparative analysis of study results ofnewborn immune system in women who received immunosuppressive chemotherapy during pregnancy. Material and methods. Physical examination of pregnant women with transplanted organs, oncological or autoimmune diseases and their newborns (n=106) was carried out. The method of flow cytometry was used for phenotyping lymphocytes in the umbilical cord blood of newborns (n=82), as well as in the venous blood of their mothers. The serum immunoglobulin’s concentration had determined of turbidimetric method. Results. We revealed the decreasing in the ratio CD3+CD4+/CD3+CD8+ and the percentage of B-lymphocytes, and the increasing of the percentage of activated T-lymphocytes in pregnant women with various pathologies who received immunosuppressive therapy. The percentage of B-lymphocytes in the umbilical cord blood of newborns was reduced. The differences in the percentage of T-lymphocytes were absent. Conclusion. The state of health in children who had born in women with immunosuppressive therapy was a satisfactory state in the early neonatal period and the changes in immune indicators were significantly less, compared with those in mothers.
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About the authors
L. V Vanko
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: lvanko@mail.ru
V. V Zubkov
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: v_zubkov@oparina4.ru
L. V Krechetova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: l_krechetova@oparina4.ru
M. I Makieva
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: m_makieva@oparina4.ru
E. N Baybarina
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: BaybarinaEN@rosminzdrav.ru
E. A Shatalova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: e_shatalova@oparina4.ru
A. C Zhukova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: a_belyaeva@oparina4.ru
N. I Klimenchenko
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: natalite@list.ru
R. G Shmakov
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation
Email: r_shmakov@oparina4.ru
References
- Ponticelli C., Moroni G. Fetal Toxicity of Immunosuppressive Drugs in Pregnancy. Clin Med. 2018; 7(12): 552. doi: 10.3390/jcm7120552
- Brewer M., Kueck A., Runowicz C.D. Chemotherapy in pregnancy. Clin. Obstet. Gynecol. 2011; 54(4): 602-18. doi: 10.1097/GRF.0b013e318236e9f9.
- Ponticelli C., Moroni G. Immunosuppression in pregnant women with systemic lupus erythematosus. Expert Rev. Clin. Immunol. 2015; 11: 549-552. doi: 10.1586/1744666X.2015.1033404
- Martin M.C., Cristiano E., Villanueva M., Bonora M.L., Berguio N., Tocci A., Groisman B. et al. Esophageal atresia and prenatal exposure to mycophenolate. Reprod. Toxicol. 2014; 50: 117-121. doi: 10.1016/j.reprotox.2014.10.015.
- Walton JR., Prasad MR. Obstetric and neonatal outcomes of cancer treated during pregnancy. Clin. Obstet. Gynecol. 2011; 54(4): 567-73. doi: 10.1097/ GRF.0b013e318236e781
- Esposito S., Tenconi R., Preti V., Groppali E., Principi N. Chemotherapy against cancer during pregnancy. Medicine (Baltimore). 2016; 95(38): e4899. doi: 10.1097/MD.0000000000004899.
- Motta M., Ciardelli L., Marconi M., Tincani A., Gasparoni A., Lojacono A., Chirico G. Immune system development in infants born to mothers with autoimmune disease, exposed in utero to immunosuppressive agents. Am. J. Perinatol. 2007; 24(8): 441-7.
- Dinelli M.S., Ono E., Viana P.O., Spina F.G., Weckx L.Y., Dos Santos A.M.N., Moraes-Pinto M. Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation. Vaccine. 2016; 34(4): 404-407. doi: 10.1016/j.vaccine.2015.12.017.
- Шаталова Е.А., Матвеева Н.К., Ванько Л.В., Кравченко Н.Ф., Жукова А.С., Макиева М.И., Кречетова Л.В., Зубков В.В. Клинико-иммунологическая характеристика новорожденных у матерей с трансплантированными органами. Акушерство и гинекология. 2018; 11: 106-113. doi: https://dx.doi. org/10.18565/aig.2018.11.106-113
- Макиева М.И., Матвеева Н.К., Ванько Л.В., Цой Т.А., Жукова А. С., Шаталова Е.А., Полушкина Е.С., Аверьянова М.В., Тимофеева Л.А., Кречетова Л.В., Зубков В.В., Шмаков Р.Г. Клинико-иммунологическая характеристика новорожденных у матерей с онкологическими заболеваниями. Акушерство и гинекология. 2017; 11: 92-99. doi: https://dx.doi.org/10.18565/ aig.2017.11.92-99
- Матвеева Н.К., Ванько Л.В., Федорова Е.В., Беляева А.С., Клименченко Н.И., Николаева М.А., Сафронова В.Г., Кошелева Н.М., Кречетова Л.В., Сухих Г.Т. Особенности клеточного звена иммунитета у беременных женщин с системной красной волчанкой и их новорожденных. Акушерство и гинекология. 2014; 12: 48-56.
- Волочаева М.В., Шмаков Р.Г., Зубков В.В. Здоровье детей, рожденных женщинами с раком молочной железы, связанным с беременностью. Акушерство и гинекология. 2014; 7: 33-37.
- Kociszewska-Najman B., Pietrzak B., Cyganek A., Szpotanska-Sikorska M., Schreiber-Zamora J., Jabiry-Zieniewicz Z., Wielgos M. Intrauterine Hypotrophy and Premature Births in Neonates Deliveredby Female Renal and Liver Transplant Recipients. Transplantation Proceedings. 2011; 43: 3048-51. doi: 10.1016/j.transproceed.2011.08.041.
- Ono E., dos Santos A. M., Viana P. O., Dinelli M. I. S., Sass N., De Oliveira L. et al. Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Femate Kidney Transplant Recipients. Am J. Transpl. 2015; 15(6): 1654-65.
- Dorner T., Jacobi A.M., Lee J., Lipsky P.E. Abnormalities of B. cell subsets in patients with systemic lupus erythematosus. J. of Immunol. Methods. 2011; 363(2): 187-197.
- Drozdowska-Szymczak A., Pietrzak B., Czaplinska N., Schreiber-Zamora J., Jabiry-Zieniewicz Z., Wielgos M., Immunological Status of Children Born to Female Liver Recipients. Ann Transplant. 2018; 23: 182-189. doi: 10.12659/ AOT.907930
- Dinelli M.I.S., Ono E., Viana P. O., Spina F. G., Weckx L.Y., dos Santos A.M.N., de Moraes-Pinto M.I. Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation. Vaccine. 2016; 34: 404-407. https://doi.org/10.1016/j.vaccine.2015.12.017
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