Metabolomic profile in pregnant women with fetal growth restriction


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Abstract

Objective. To search for biomarkers of fetal growth restriction (FGR) based on a study of the metabolic profile of pregnant women. Subjects and methods. Plasma samples from 38 pregnant women were investigated during the study. The pregnant women were divided into two groups: 1) 17 pregnant women with FGR; 2) 21 women with physiological pregnancy. The samples were analyzed using liquid chromatography with mass spectrometric detection. Control of the analysis of experimental results and their processing were done applying Agilent MassHunter software. Results. The investigators identified 18 metabolites min with statistically significantly different levels. Correlation analysis established a signif icant relationship between the identif ied metabolites and clinical and anamnestic data. There was a moderate correlation of FGR with 3 amino acids: beta-alanine (rs = 0.413, p = 0.003), cysteine (rs = 0.588, p <0.001), and ornithine (rs = 0.427, p = 0.002). Conclusion. The findings substantiate the prospects of investigating beta-alanine, cysteine, and ornithine as diagnostic markers of FGR. The high correlation of these metabolites with Doppler readings determines the possibility of their inclusion in the integrated diagnosis of FGR.

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About the authors

Natalia E. Kan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru

Zarine V. Khachatryan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: z.v.khachatryan@gmail.com

Elrad Yu. Amiraslanov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_amiraslanov@oparina4.ru

V. V Chagovets

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: vvchagovets@gmail.com

Victor L. Tyutyunnik

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru

Natalia A. Lomova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: natasha-lomova@yandex.ru

N. L Starodubtseva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_starodubtseva@oparina4.ru

Natalia A. Kitsilovskaya

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kitsilovskyana@gmail.com

Igor I. Baranov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: i_baranov@oparina4.ru

Vladimir E. Frankevich

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_frankevich@oparina4.ru

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