Key diagnostic criteria for adolescent polycystic ovary syndrome adjusted for age-specific hormonal and metabolic status standard


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Abstract

Aim. To specify the diagnostic criteria, clinical and laboratory features of PCOS in female adolescents. Materials and methods. The study comprised 130 girls aged 15 to 17 years with PCOS diagnosed by the Rotterdam criteria. The control group consisted of 30 healthy girls of a similar age with a regular menstrual cycle. The study participants underwent a complete clinical and laboratory workup with an expanded hormonal prof ile and a pelvic ultrasound examination. Results. Highly specific PCOS markers in girls aged 15-17 years include oligo- or amenorrhea with menarche and hirsutism, an ovarian volume of both ovaries > 10.70 cm3, ovarian-uterine index > 3.95, LH/FSH ratio> 1.23, AMH level> 7.20 ng/ml, testosterone > 1.15 nmol /L, and androstenedione > 11.45 ng/ml with a free androgen index > 2.75 (for each criterion, sensitivity and specificity is 75.0-93.0% and 0 83.0-93.0%, respectively). The diagnostic accuracy of PCOS reaches 92% with the logistic regression equation as follows: logit = 85.73- (1.73 x AMH) - (0.12 x Leptin) less than 70.72. Conclusion. The study determined threshold levels of AMH, free androgen index, androstenedione, testosterone, LH/FSH, values of ovarian volume and ovarian-uterine index, which have high sensitivity and specif icity and may be recommended for the diagnosis of PCOS in patients aged 15 - 17 years.

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About the authors

Elena P. Khashchenko

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: khashchenko_elena@mail.ru
Candidate of Medical Sciences, Researcher 2nd gynecological department (gynecology of children and adolescents)

Elena V. Uvarova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: elena-uvarova@yandex.ru
MD, professor, head of the 2nd gynecological department (gynecology of children and adolescents)

Tatyana Y. Ivanets

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: t_ivanets@oparina4.ru
MD, Head of the Clinical Diagnostic Laboratory

Fatima Sh. Mamedova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: mamedova_f@mail.ru
candidate of medical sciences, doctor of the department of ultrasound diagnostics in neonatology and pediatrics

Mikhail Y. Vysokikh

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: m_vysokikh@oparina4.ru
candidate of biological sciences, Head. mitochondrial medicine laboratory

Pavel I. Borovikov

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: p_borovikov@oparina4.ru
Head. bioinformatics laboratory

Ivan S. Balashov

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: i_balashov@oparina4.ru
specialist of the bioinformatics laboratory

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