INFLUENCE OF NONABLATIVE RADIOFREQUENCY ON THE EXPRESSION OF CONNECTIVE TISSUE PROTEINS IN THE UROGENITAL TRACT IN PATIENTS WITH VAGINAL RELAXATION SYNDROME DURING THE POSTPARTUM PERIOD


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Abstract

Objective. To determine the influence of radiofrequency (RF) on the mRNA expression of connective tissue proteins in the genital tract in patients with vaginal relaxation syndrome during the postpartum period. Subjects and methods. Thirty patients who had undergone a cycle of radiofrequency vulvovaginal tightening according to the standard protocol took part in the study 2 months following childbirth. The results were assessed a month after the end of the cycle. The mRNA and protein expression of collagen genesis was analyzed by realtime PCR. Results. During the treatment performed, the expression of decorin mRNA decreased by 9.7 times (p = 0.02), collagen type III by 6.2 times (p = 0.03), and matrix metalloproteinase type II by 1.3 times (p = 0.03). Conclusion. Our findings confirm the influence of RF on the expression of genital tract connective tissue proteins in patients with pelvic floor dysfunction in the postpartum period.

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About the authors

Yulia E. Dobrokhotova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

MD, professor, Head of the Department of Obstetrics and Gynecology of the medical faculty Moscow, Russia

Tamara S.K. Nagieva

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

postgraduate student of the Department of the Obstetrics and Gynecology of the medical faculty Moscow, Russia

Irina Yu. Il’ina

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

MD, Associate Professor of the Department of Obstetrics and Gynecology of the medical faculty Moscow, Russia

Elena N. Kareva

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

MD, professor of the Department of Molecular Pharmacology Moscow, Russia

Nataliya A. Kochina

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Ph.D, Senior Researcher of the Research Laboratory of Molecular Pharmacology Moscow, Russia

Elena V. Zraguz

Maternity Hospital One, L.A. Vorokhobov City Clinical Hospital Sixty-Seven (Branch)

obstetrician-gynecologist of the highest category, the head of the 2nd obstetric physiology department Moscow, Russia

Anna B. Dobrova

Maternity Hospital One, L.A. Vorokhobov City Clinical Hospital Sixty-Seven (Branch)

obstetrician-gynecologist of the first category, the Head of the maternity home branch Moscow, Russia

Irina A. Shakhmartova

MEDSI-2 Clinical Diagnostic Center

the doctor of the highest category, obstetrician-gynecologist, Head of the Women’s Health Department Moscow, Russia

Ekaterina V. Krasnoschok

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

student Moscow, Russia

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