Assessment of hemostatic function in women with a history of recurrent pregnancy loss using thrombodynamics and blood clot contraction tests


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Abstract

Aim. To identify hemostatic abnormalities in non-pregnant patients with a history of recurrent pregnancy loss (RPL). Materials and methods. Thirty-five patients with RPL and 25 parous women without a complicated obstetric history underwent clinical evaluation including thrombodynamics test and the measurement of blood clot contraction kinetics. Results. Patients with a history of RPL had a statistically significantly higher hypercoagulability and a significant decrease in the ability of the clot to contract. Patients with three or more pregnancy losses have a statistically significantly higher hypercoagulability and greater changes in clot contraction, compared with patients who lost one or two pregnancies. Besides, miscarriages after 10 weeks’ gestation were associated with a greater decrease in clot contraction than early miscarriages. Conclusion. Chronic hypercoagulable state and decreased blood clot contraction form a premorbid background in women with RPL. These findings suggest the possibility of using thrombodynamics and blood clot contraction as diagnostic tests to identify women at high risk of pregnancy loss.

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About the authors

Alina D. Peshkova

Kazan Federal University

Email: alinapeshkova26@gmail.com

Svetlana I. Safiullina

Aibolit Medical Center; Kazan State Medical University

Email: Svetlana.ild.saflullina@gmail.com

Dinare G. Asarova

Kazan Federal University

Email: didi-lady@yandex.ru

Aigul F. Khafizova

Kazan Federal University

Email: aii2022i02@gmail.com

Fazoil I. Ataullakhanov

Center for Theoretical Problems of Physicochemical Pharmacology

Email: ataullakhanov.fazly@gmail.com

Rustem I. Litvinov

Kazan Federal University; University of Pennsylvania

Email: litvinov@pennmedicine.upenn.edu

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