Experience of application of activated glycyrrhizic acid.in vulvovaginitis, cervicitis, and genital papillomavirus infection
- Authors: Rakhmatulina M.R.1, Bolshenko N.V.2,3, Lipova E.V.1
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Affiliations:
- State Research Center of the Russian Federation - A.I. Burnazyan Federal Medical and Biophysical Center, Federal Biomedical Agency of Russia
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Moscow Regional Clinical Dermatovenereology Dispensary
- Issue: No 9 (2019)
- Pages: 153-158
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248707
- DOI: https://doi.org/10.18565/aig.2019-9.153-158
- ID: 248707
Cite item
Open Access
Access granted
Abstract
Objective: to evaluate the clinical efficacy of Epigen Intim, 0.1% spray, in patients with vulvovaginitis and/or cervicitis of nonspecific etiology and in those with genital papillomavirus infection (PVI). Subjects and methods. The investigation enrolled 60patients aged 18 to 56 years: Group 1 included 30patients with the clinical and laboratory signs of vulvovaginitis and/or cervicitis; Group 2 comprised 30 patients with PVI and HPV values of> 3 lg DNA copies per 100,000cells. All the patients were prescribed Epigen Intim, 0.1% spray, thrice daily intravaginally; it was additionally used topically in Group 2 patients (with the clinical manifestations of PVI). The treatment cycle for Groups 1 and 2 patients was 10 and 30 days, respectively. Results. After the treatment, there was a significant decrease in the detection rates for the subjective and objective signs of urogenital inflammatory diseases; normalization of leukocyte responses in the vagina (96.7%) and cervical canal (83.3%); reversion of the clinical manifestations of PVI (60.0%); elimination (20.0%) or a decrease in the HPV values to less than 3.0 lg HPV DNA copies per 100,000 cells (26.7%); and an improvement in the cytological examination of cervical scrapings (20.0%). Conclusion. Epigen Intim, 0.1% spray, showed a high efficiency profile in the treatment of urogenital infections and can be recommended as an anti-inflammatory, antiviral and immunostimulating agent for the treatment of vulvovaginitis, cervicitis, and genital PVI.
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About the authors
Margarita R. Rakhmatulina
State Research Center of the Russian Federation - A.I. Burnazyan Federal Medical and Biophysical Center, Federal Biomedical Agency of Russia
Email: ra.marg@yandex.ru
MD, professor, professor of the Department of dermatovenerology and cosmetology with a course of clinical laboratory diagnostics
Natalya V. Bolshenko
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Moscow Regional Clinical Dermatovenereology Dispensary
Email: sanabol@mail.ru
candidate of medical sciences, the head researcher
Elena V. Lipova
State Research Center of the Russian Federation - A.I. Burnazyan Federal Medical and Biophysical Center, Federal Biomedical Agency of Russia
Email: elipova97@icloud.com
MD, Professor, Head of the Department of dermatovenerology and cosmetology with a course of clinical laboratory diagnostics
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