The features of the course of pregnancy and its outcomes in women vaccinated against papillomavirus infection


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Abstract

Objective. To investigate the features of the course of pregnancy and labor and the health status of newborn babies born to HPV-positive mothers and women who had undergone vaccination against papillomavirus infection (PVI) in adolescence. Subjects and methods. A survey was conducted in 440 women aged 18 to 36 years, who were divided into 2 groups: 1) HPV-negative patients, who undergone vaccination against PVI mainly in adolescence, as well as at reproductive age; 2) HPV-positive patients who had not been vaccinated or treated for PVI. The course of pregnancy, its complications, as well as outcomes and neonatal health status were studied in the comparison groups. Results. Gestational and postnatal complications were found to have much less common in the group of women who had undergone quarivalent HPV vaccination than in that of HPV-positive patients who had not been vaccinated and treated for PVI during pregnancy. Conclusion. The findings showed that HPV vaccination itself had a pronounced effect on the onset of pregnancy, its course and outcome in the mother and fetus, as well as safety. These investigations require further consideration and studies of a number of issues related to the follow-up of an infant and his/her immunity, as well as confirm the need for urgent inclusion of vaccination in Russia’s immunization schedule for teenagers.

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About the authors

Vladislav I. Krasnopolsky

Moscow Regional Research Institute of Obstetrics and Gynecology

MD, Acad. RAS, Professor, President 101000 Russia, Moscow, ul. Pokrovka, 22A

Vasily A. Petrukhin

Moscow Regional Research Institute of Obstetrics and Gynecology

MD, professor, director 101000 Russia, Moscow, ul. Pokrovka, 22A

Nina V. Zarochentseva

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: ninazar11@mail.ru
MD, Professor of the Russian Academy of Sciences, Deputy Director for Research 101000 Russia, Moscow, ul. Pokrovka, 22A

Yulia M. Belaya

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: belajay@yandex.ru
PhD, researcher at the outpatient department 101000 Russia, Moscow, ul. Pokrovka, 22A

Irina I. Bocharova

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: 567891@mail.ru
MD, Leading Researcher, MONIIAG, Doctor of the highest qualification category in the specialty “Neonatology” 101000 Russia, Moscow, ul. Pokrovka, 22A

Valeriya A. Vodovatova

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: leleronik@gmail.com
Junior Researcher, neonatologist, resuscitation anesthetist 101000 Russia, Moscow, ul. Pokrovka, 22A

Lyudmila V. Keshiyan

Naro-Fominsk Perinatal Center

PhD, head physician Russia, Moscow region, Naro-Fominsk. st. Kalinina, d. 30

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