Correction of climacteric disorders in patients with breast cancer: current methods and prospects


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Abstract

Treatment of menopausal syndrome in patients with breast cancer is aimed not only at maintaining the quality of life, but also at increasing life expectancy, including by reducing refusal rates of anti-recurrence therapy. The most effective treatment option is menopausal hormone therapy, which, with some exceptions, is contraindicated in patients with breast cancer. Phytoestrogens and serotonin-norepinephrine reuptake inhibitors are an alternative to relieve vasomotor symptoms. If non-hormonal treatment of genitourinary menopausal syndrome has no effect, estrogens should be considered for vaginal treatment. Promising treatment modalities include a tissue-selective estrogen complex, estetrol, ospemifene and vaginal dehydroepiandrosterone. Loss of bone mineral density and fractures in breast cancer patients has many causes. Effective treatments include bisphosphonates and denosumab.

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About the authors

Antonina A. Smetnik

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: a_smetnik@oparina4.ru

Valeriy V. Rodionov

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: V_Rodionov@oparina4.ru

Vlada V. Kometova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: v_kometova@oparina4.ru

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