Risk factors for endometriosis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The increased incidence of endometriosis is due both to improved diagnosis, a larger number of surgical interventions and the increasing influence of various risk factors. The paper analyzes the data available in the literature on risk factors for endometriosis. It is indicated that the risk factors for endometriosis depend on a female patient’s age from the antenatal period to adulthood, as well as have certain differences in various countries and regions. The modifiable factors include diet, environmental influences, parity, breastfeeding duration, and physical activity. Other factors, such as genetic factors, early menarche, and the length of the menstrual cycle, are considered unmodifiable. It is emphasized that the presence of several risk factors can serve as the basis for classifying these women as a separate risk group, as well as for making a special more thorough examination to identify the foci of endometriosis.

Full Text

Restricted Access

About the authors

Ulyana N. Tumanova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru
PhD, senior researcher at the Department of Morbid Anatomy

Aleksandr I. Shchegolev

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru
MD, professor, head of the Department of Morbid Anatomy

Stanislav V. Pavlovich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: s_pavlovich@oparina4.ru
MD, scientific secretary; Professor of the Department of Obstetrics, Gynecology and Perinatology

Vladimir N. Serov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_serov@oparina4.ru
MD, professor, academician of the Russian Academy of Sciences, chief researcher

References

  1. Moen M.H., Schei B. Epidemiology of endometriosis in a Norwegian county. Acta Obstet Gynecol Scand. 1997; 76: 559-62. doi: 10.3109/00016349709024584
  2. Meuleman C., Vandenabeele B., Fieuws S., Spiessens C., Timmerman D., D’Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009; 92: 68-74. doi: 10.1016/j.fertnstert.2008.04.056
  3. Liston W.A., Bradford W.P., Downie J., Kerr M.G. Laparoscopy in a general gynecologic unit. Am J. Obstet Gynecol. 1972; 113: 672-7. doi: 0002-9378(72)90636-9
  4. Buck Louis G.M., Hediger M.L., Peterson C.M., Croughan M., Sundaram R., Stanford J. , et al. Incidence of endometriosis by study population and diagnostic method: the ENDO study. Fertil Steril. 2011; 96: 360-5. doi: 10.1016/j. fertnstert.2011.05.087
  5. Giudice L.C., Kao L.C. Endometriosis. Lancet. 2004; 364 (9447): 1789-99. doi: 10.1016/S0140-6736(04)17403-5
  6. Yamamoto A., Johnstone E.B., Bloom M.S., Huddleston H.G., Fujimoto V.Y. A higher prevalence of endometriosis among Asian women does not contribute to poorer IVF outcomes. J. Assist Reprod Genet. 2017; 34: 765-74. doi: 10.1007/ s10815-017-0919-1
  7. Hudelist G., Fritzer N., Thomas A., Niehues C., Oppelt P., Haas D., et al. Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences. Hum Reprod. 2012; 27: 3412-6. doi: 10.1093/humrep/des316
  8. Щеголев А.И., Быков А.Г., Туманова У.Н., Павлович С.В. Эндометриоз и развитие опухолей. Акушерство и гинекология. 2016; 11: 49-56.
  9. Harada T., ed. Endometriosis. Pathogenesis and treatment. Springer, 2014. 477 p. doi: 10.1007/978-4-431-54421-0
  10. Vannuccini S., Lazzeri L., Orlandini C., Tosti C., Clifton V.L., Petraglia F. Potential influence of in utero and early neonatal exposures on the later development of endometriosis. Fertil Steril. 2016; 105(4): 997-1002. doi: 10.1016/j.fertnstert.2015.12.127
  11. Kashima K., Ishimaru T., Okamura H., Suginami H., Ikuma K., Murakami T. et al. Familial risk among Japanese patients with endometriosis. Int J. Gynaecol Obstet. 2004; 84: 61-4. doi: 10.1016/s0020-7292(03)00340-0
  12. Vigano P., Somigliana E., Vignali M., Busacca M., Blasio A.M. Genetics of endometriosis: current status and prospects. Front Biosci. 2007; 1: 3247-55. doi: 10.2741/2308
  13. Пономаренко И.В., Полоников А.В., Чурносов М.И. Молекулярные механизмы и факторы риска развития эндометриоза. Акушерство и гинекология. 2019; 3: 26-31. doi: 10.18565/ aig.2019.3.26-31
  14. Rahmioglu N., Nyholt D.R., Morris A.P., Missmer S.A., Montgomery G.W., Zondervan K.T. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update. 2014; 20: 702-16. doi: 10.1093/humupd/dmu015
  15. Yen C.F., Kim M.R., Lee C.L. Epidemiologic Factors Associated with Endometriosis in East Asia. Gynecol Minim Invasive Ther. 2019; 8(1): 4-11. doi: 10.4103/GMIT.GMIT_83_18
  16. Cho Y.J., Kim N.H., Jeong K.A., Lee J.Y., Moon H.S., Kim H.L., et al. Association between MMP-2 and TIMP-2 gene polymorphisms and advanced-stage endometriosis in Korean women. Am J. Reprod Immunol. 2013; 69: 73-84. doi: 10.1111/aji.12020
  17. Shan K., Xiao-Wei M., Na W., Xiu-Feng Z., Deng-Gui W., Wei G., et al. Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Reproduction. 2007; 134: 373-8. doi: 10.1530/REP-07-0104
  18. Birt J.A., Taylor K.H., Davis J.W., Sharpe-Timms K.L. Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos. Fertil Steril. 2013; 100: 1436-43. doi: 10.1016/j.fertnstert.2013.07.007
  19. Stilley J.A., Woods-Marshall R., Sutovsky M., Sutovsky P., Sharpe-Timms K.L. Reduced fecundity in female rats with surgically induced endometriosis and in their daughters: a potential role for tissue inhibitors of metalloproteinase 1. Biol Reprod. 2009; 80: 649-56. doi: 10.1095/biolreprod.108.073411
  20. Patel B., Elguero S., Thakore S., , Dahoud W., Bedaiwy M., Mesiano S. Role of nuclear progesterone receptor isoforms in uterine pathophysiology. Hum Reprod Update. 2015; 21: 155-73. doi: 10.1093/humupd/dmu056
  21. Maclaran K., Agarwal N., Odejinmi F. Co-existence of uterine myomas and endometriosis in women undergoing laparoscopic myomectomy: risk factors and surgical implications. J. Minim Invasive Gynecol. 2014; 21: 1086-90. doi: 10.1016/j.jmig.2014.05.013
  22. Missmer S.A., Hankinson S.E., Spiegelman D., Barbieri R.L., Michels K.B., Hunter D.J. In utero exposures and the incidence of endometriosis. Fertil Steril. 2004; 82: 1501-8. doi: 10.1016/j.fertnstert. 2004.04.065
  23. Mazzuca M.Q., Wlodek M.E., Dragomir N.M., Parkington HC, Tare M. Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring. J. Physiol. 2010; 588: 1997-2010. doi: 10.1113/jphysiol.2010.187849
  24. Gondret F., Pere M.C., Tacher S., Dare S., Trefeu C., le Huberou-Luron I., et al. Spontaneous intrauterine growth restriction modulates the endocrine status and the developmental expression of genes in porcine fetal and neonatal adipose tissue. Gen Comp Endocrinol. 2013; 1: 208-16. doi: 10.1016/j. ygcen.2013.09.018
  25. Farland L.V., Missmer S.A., Bijon A., Gusto G., Gelot A., Clavel-Chapelon F., et al. Associations among body size across the life course, adult height and endometriosis. Hum Reprod. 2017; 32: 1732-42. doi: 10.1093/ humrep/dex207
  26. Yi K.W., Shin J.H., Park M.S., Kim T., Kim S.H., Hur J.Y. Association of body mass index with severity of endometriosis in Korean women. Int J. Gynaecol Obstet. 2009; 105: 39-42. doi: 10.1016/j.ijgo.2008.11.001
  27. Raimondo D., Mabrouk M., Zannoni L., Arena A., Zanello M., Benfenati A., et al. Severe ureteral endometriosis: frequency and risk factors. J. Obstet Gynaecol. 2018; 38: 257-60. doi: 10.1080/01443615.2017.1349083
  28. Shah D.K., Correia K.F., Vitonis A.F., Missmer S.A. Body size and endometriosis: results from 20 years of follow-up within the Nurses’ Health Study II prospective cohort. Hum Reprod. 2013; 28: 1783-92. doi: 10.1093/humrep/ det120
  29. McCann S.E., Freudenheim J.L., Darrow S.L., Batt R.E., Zielezny M.A. Endometriosis and body fat distribution. Obstet Gynecol. 1993; 82: 545-9. PMID: 8377980
  30. Cramer D.W., Wilson E., Stillman R.J., Berger M.J., Belisle S., Schiff I., et al. The relation of endometriosis to menstrual characteristics, smoking, and exercise. JAMA. 1986; 255: 1904-8. PMID: 3951117
  31. Saha R., Kuja-Halkola R., Tornvall P., Marions L. Reproductive and lifestyle factors associated with endometriosis in a large cross-sectional population sample. J. Womens Health (Larchmt). 2017; 26: 152-8. doi: 10.1089/ jwh.2016.5795
  32. Missmer S.A., Hankinson S.E., Spiegelman D., Barbieri R.L., Malspeis S., Willett W.C., et al. Reproductive history and endometriosis among premenopausal women. Obstet Gynecol. 2004; 104: 965-74. doi: 10.1097/01. AOG.0000142714.54857.f8
  33. Vercellini P., Eskenazi B., Consonni D., Somigliana E., Parazzini F., Abbiati A., et al. Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2011; 17: 159-70. doi: 10.1093/humupd/ dmq042
  34. Paris K., Aris A. Endometriosis-associated infertility: A decade’s trend study of women from the Estrie Region of Quebec, Canada. Gynecol Endocrinol. 2010; 26: 838-42. doi: 10.3109/09513590.2010.487590
  35. Prescott J., Farland L.V., Tobias D.K., Gaskins A.J., Spiegelman D., Chavarro J.E., et al. A prospective cohort study of endometriosis and subsequent risk of infertility. Hum Reprod. 2016; 31: 1475-82. doi: 10.1093/humrep/dew085
  36. Upson K., Sathyanarayana S., Scholes D., Holt V.L. Early-life factors and endometriosis risk. Fertil Steril. 2015; 104: 964-71. doi: 10.1016/j. fertnstert.2015.06.040
  37. Dubova E.A., Pavlov K.A., Lyapin V.M., Shchyogolev A.I., Sukhikh G.T. Vascular endothelial growth factor and its receptors in the placental villi of pregnant patients with pre-eclampsia. Bull. Exp. Biol. Med. 2013; 154(6): 792-5. doi: 10.1007/s10517-013-2058-8
  38. Воднева Д.Н., Романова В.В., Дубова Е.А., Павлов К.А., Шмаков Р.Г., Щеголев А.И. Клинико-морфологические особенности ранней и поздней преэклампсии. Акушерство и гинекология. 2014; 2: 35-40. [Vodneva D.N., Romanova V.V., Dubova E.A., Pavlov K.A., Shmakov R.G., Shchegolev A.I. The clinical and morphological features of early and late-onset preeclampsia. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2014; 2: 35-40. (in Russian)]/
  39. Jefferson W.N., Patisaul H.B., Williams C.J. Reproductive consequences of developmental phytoestrogen exposure. Reproduction 2012; 143: 247-60. doi: 10.1530/REP-11-0369
  40. McCarver G., Bhatia J., Chambers C., Clarke R., Etzel R., Foster W., et al. NTP-CERHR expert panel report on the developmental toxicity of soy infant formula. Birth Defects Res. B. Dev. Reprod. Toxicol. 2011; 92: 421-68. doi: 10.1002/ bdrb.20314
  41. Mvondo M.A., Ekenfack J.D., Essono S.M., Namekong H.S., Awounfack S.F., Laschke M.W., et al. Soy intake since the prepubertal age may contribute to the pathogenesis of endometriosis in adulthood. J. Med Food. 2019; 22(6): 631-8. doi: 10.1089/jmf.2018.0160
  42. Hoffman C.S., Small C.M., Blanck H.M., Tolbert P., Rubin C., Marcus M. Endometriosis among women exposed to polybrominated biphenyls. Ann Epidemiol. 2007; 17: 503-10. doi: 10.1016/j.annepidem. 2006.11.005
  43. Eskenazi B., Mocarelli P., Warner M., Samuels S., Vercellini P., Olive D., et al. Serum dioxin concentrations and endometriosis: a cohort study in Seveso, Italy. Environ Health Perspect. 2002; 110: 629-34. doi: 10.1289/ ehp.02110629
  44. Yasui T., Hayashi K., Nagai K., Mizunuma H., Kubota T., Lee J.S., et al. Risk profiles for endometriosis in Japanese women: Results from a repeated survey of self-reports. J. Epidemiol. 2015; 25: 194-203. doi: 10.2188/ jea.JE20140124
  45. Kvaskoff M., Bijon A., Clavel-Chapelon F., Mesrine S., Boutron-Ruault M.C. Childhood and adolescent exposures and the risk of endometriosis. Epidemiology. 2013; 24: 261-9. doi: 10.1097/EDE.0b013e3182806445
  46. Missmer S.A., Chavarro J.E., Malspeis S., Bertone-Johnson E.R., Hornstein M.D., Spiegelman D., et al. A prospective study of dietary fat consumption and endometriosis risk. Hum Reprod. 2010; 25: 1528-35. doi: 10.1093/humrep/ deq044
  47. Savaris A.L., do Amaral V.F. Nutrient intake, anthropometric data and correlations with the systemic antioxidant capacity of women with pelvic endometriosis. Eur J. Obstet Gynecol Reprod Biol. 2011; 158: 314-8. doi: 10.1016/j.ejogrb.2011.05.014
  48. Shafrir A.L., Farland L.V., Shah D.K., Harris H.R., Kvaskoff M., Zondervan K. et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018; 51: 1-15. doi: 10.1016/ j.bpobgyn.2018.06.001
  49. Chiaffarino F., Bravi F., Cipriani S., Parazzini F., Ricci E., Vigano P., et al. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur J. Nutr. 2014; 53: 1573-9. doi: 10.1007/s00394-014-0662-7
  50. Heilier J.F., Donnez J., Nackers F., Parazzini F., Ricci E., Vigano P., et al. Environmental and host-associated risk factors in endometriosis and deep endometriotic nodules: a matched case-control study. Environ Res. 2007; 103: 121-9. doi: 10.1016/j.envres.2006.04.004
  51. Vitonis A.F., Hankinson S.E., Hornstein M.D., Missmer S.A. Adult physical activity and endometriosis risk. Epidemiology. 2010; 21: 16-23. doi: 10.1097/ EDE.0b013e3181c15d40
  52. Schernhammer E.S., Vitonis A.F., Rich-Edwards J., Missmer S.A. Rotating nightshift work and the risk of endometriosis in premenopausal women. Am J. Obstet Gynecol. 2011; 205: 476 e1-8. doi: 10.1016/j.ajog.2011.06.002

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies