The association between rs2414098 polymorphism of the CYP19A1 gene and the risk of developing endometrial hyperplasia


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Abstract

Objective. To assess the prevalence of CYP19A1 rs2414098polymorphism and to identify its association with the risk of endometrial hyperplasia in women. Subjects and methods. The investigation enrolled 180 female residents of the Republic of Tatarstan. A study group consisted of 79patients with endometrial hyperplasia without atypia; a control group included 101 women without endometrial pathology. DNA samples were genotyped for CYP19A1 rs2414098 polymorphism with a real-time polymerase chain reaction assay. A chi-square test was carried out; an odds ratio was also estimated. Results. The C allele and the C/C genotype of CYP19A1 rs2414098polymorphism are the factors that increase the risk of endometrial hyperplasia without atypia in women living in the Republic of Tatarstan. The prevalence of the alleles and genotypes of CYP19A1 rs2414098proved to be comparable to the European sample data. Overweight (BMI >25 kg/m2) was also found to be a risk factor for endometrial hyperplasia, which was independent of the CYP19A gene predictor. Conclusion. The investigation has revealed that there are associations of the CYP19A1 rs2414098polymorphism with the risk of endometrial hyperplasia without atypia.

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About the authors

Ildar F. Fatkullin

Kazan State Medical University, Ministry of Health of the Russian Federation

Email: fatkullin@yandex.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology named after V.S. Gruzdev

Rushanija I. Gabidullina

Kazan State Medical University, Ministry of Health of the Russian Federation

Email: ru.gabidullina@yandex.ru
MD, Professor of the Department of Obstetrics and Gynecology named after V.S. Gruzdev

Gulnaz A. Smirnova

Kazan City Clinical Hospital Seven

Email: s89274281088@yandex.ru
gynecologist

Fikret R. Nukhbala

Kazan State Medical University, Ministry of Health of the Russian Federation

Email: nuhbala_fikret@mail.ru
postgraduate student of the Department of Obstetrics and Gynecology named after V.S. Gruzdev

Elena V. Valeeva

Kazan State Medical University, Ministry of Health of the Russian Federation

Email: vevaleeva@ya.ru
Junior Researcher of the Laboratory of Molecular Genetics, Central Research Laboratory

Yuliya I. Orlova

Kazan State Medical University, Ministry of Health of the Russian Federation

Email: juliaorloval8@gmail.com
6th year student of the pediatric faculty

Arseny A. Shakirov

Kazan State Medical University, Ministry of Health of the Russian Federation

Email: arseniy.shakirov@kazangmu.ru
5th year student of the medical faculty

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