Empirical therapy for vulvovaginitis in reproductive-aged women in routine clinical practice


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Abstract

Objective. To evaluate the eff iciency of empirical therapy with tergynan in reproductive-aged women in routine clinical practice. Subjects and methods. The TERRA multicenter post-registration observational study enrolled 430 reproductive-aged patients diagnosed with acute vulvovaginitis. Based on their complaints, clinical symptoms, and objective examination, the patients received empirical therapy with the combination antimicrobial drug Tergynan as a single vaginal tablet once daily for 10 days. Gynecological examination, pH-metry, and bacterioscopic and bacteriological examinations of discharge (Femoflor-16) were performed, and the time course of changes in clinical symptoms evaluated. Results. There was less vaginal discharge, a complete disappearance of unpleasant odor, and a feeling of vaginal itching and burning (74.5 and 67.1%, respectively). There were increases in the detection rate of Lactobacillus spp. by 2 times with a dissemination level of 106-107 CFU/ml, in the suppression of obligate anaerobic representatives (associations of Gardnerella vaginalis + Prevotella bivia + Porphyromonas spp., as well as Eubacterium spp.) by 5 times, facultative anaerobic bacteria (Enterobacteriaceae and Streptococcus spp.) by 3 times, and yeast-like fungi of the genus Candida by 2 times. Conclusion. This investigation demonstrated the high clinical (96.5%) and microbiological (97.3%) efficiency of empirical therapy with tergynan in 430 reproductive-aged women with acute nonspecific vulvovaginitis

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About the authors

Victor E. Radzinsky

RUDN University

Email: radzinsky@mail.ru
Merit scientist of the Russian Federation, corresponding member RAS, Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology with a course of perinatology of the Medical Institute

Vitaliya G. Anufrieva

Rostov State Medical University

Email: vitaliya@list.ru
obstetrician-gynecologist, gynecologic department

Antonina A. Belinina

FSBEI HE “Altai State Medical University”; KGBUZ “Altai Regional Clinical Perinatal center

candidate of medical sciences, assistant of the Department Obstetrics and Gynecology with a course DPO; deputy chief physician for quality control and safety of medical activities

Angelina V. Bespalaya

State Perinatal center of the Rostov region

Email: angelina-koshka@yandex.ru
оbstetrician-gynecologist of the birth Department

Valentina F. Dolgushina

South Ural State Medical University

Email: dolgushinavf@yandex.ru
Doctor of Medicine, professor, Head of the Department of Obstetrics and Gynecology, the Main freelance obstetrician-gynecologist for children and adolescents of the Ministry of Health of the Chelyabinsk Region.

Ekaterina Y. Zhilno

Saratov State Medical University

Candidate of Medical Sciences, Assistant of the Department

Irina E. Zazerskaya

FSBISRC named after V.A. Almazova

Email: zazerskaya@almazovcentre.ru
Doctor of Medicine, Professor, Head of the Department of Obstatrics and Gynecology

Nadezhda Y. Katkova

Volga Research Medical University

Email: katkova_nu@inbox.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology

Olga I. Klimova

FNMO

Email: koiv0l@mail.ru
Candidate of Medical Sciences, Associate Professor, Department of Obstetrics, Gynecology and Reproductive Medicinel

Irina N. Korotkikh

FSBEI HE“Voronezh State Medical University named after N.N. Burdenko

Email: korotkikh_l950@mail.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology No. l, Faculty of Medicine

Elena N. Kravchenko

Omsk State Medical University

Email: kravchenko.en@mail.ru
Doctor of Medicine, professor, Head of the Department of Obstetrics and Gynecology DPO

Irina G. Kutsenko

Siberian State Medical University

Email: irinakutcenko@mail.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology

Elizaveta Yu. Lebedenko

Rostov State Medical University

Email: Lebedenko08@mail.ru
Doctor of Medicine, Professor of the Department of Obstetrics and Gynecology

V. V Loseva

Immanuel Kant Baltic Federal University

Natalia V. Mingaleva

KubSMU

Email: mingalevan008@yandex.ru
MD, pMD, professor of the Department of Obstetrics and gynecology FPK and PPS, chief freelance specialist for outpatient obstetric and gynecological care of the Ministry of Health of the Krasnodar Krai

Irina V. Molchanova

Altai Territory Perinatal Center

Email: Molcanova2008@yandex.ru
Chief freelance specialist in obstetrics and gynecology of the Altai Territory, Chief physician

Irina M. Ordiyants

RUDN University

Email: ordiyantc@mail.ru
MD, professor of the Department of Obstetrics and Gynecology with a course of perinatolo gy of the Medical Institute

Mikhail M. Padrul

Perm State Medical University named after Academician E.A. Wagner

Email: m-padrul@mail.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology

Alexander I. Pashov

Immanuel Kant Baltic Federal University

Email: pachov@mail.ru
MD, professor, head of the Department of Obstetrics and Gynecology

Natalia V. Protopopova

IGMAPO - branch of FSBEI DPO RMANPO

Email: doc_protopopova@mail.ru
MD, professorMD, professor, Head of the Department of Obstetrics and Gynecology

Elena A. Rosyuk

FSBEI HE «UMMU»

Email: elenakdc@yandex.ru
candidate of medical sciences, associate professor of the Department Obstetrics and Gynecology

Mikhail A. Rymashevsky

Rostov State Medical University

Email: mikhail.rymashevskiy@mail.ru
assistant of the Department of Obstetrics and Gynecology

Natalya V. Sablina

City Clinical Hospital named after S.P. Botkin, Department of Health in Moscow

Email: natalie_sablina@yahoo.de
obstetrician-gynecologist, gynecologic department

Igor A. Salov

State Health Institution Saratov City Clinical Hospital No. 1 named after Yu. Y. Gordeeva

Email: salov.i.a@mail.ru
MD, professor. chief freelance specialist in obstetrics and gynecology of the Saratov region, chief doctor

Tatyana M. Sokolova

NSMU

Email: tatyana3965@mail.ru
MD, professor of the Department of Obstetrics and Gynecology of the medical faculty

Natalya V. Spiridonova

Samara State Medical University

Email: nvspiridonova@mail.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology IPO Samara State Medical University, Chief freelance specialist in Obstetrics and Gynecology of the Samara region

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