Antiphospholipid antibody profile, immunochemical properties, and diagnostic value in women with early recurrent spontaneous miscarriage


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Abstract

Antiphospholipid antibodies (aPL), a heterogeneous group of autoantibodies, have a pathogenetic and diagnostic value for obstetric APS. Aim.0h RSM were 3.4-8.5 times more likely to be positive for antibodies against β2-glycoprotein-I (β2-GP-I), cardiolipin (CL), annexin A5 (An A5), phosphatidylserine/prothrombin complex (PS/PT), and phosphatidylethanolamine (PE) than healthy women. Serum level of IgG antibodies to β2-GP-L >17.6 U/ml was associated with a high probability of the presence of antibodies to domain I. IgG2 subclass of aPL with moderate and high levels of avidity were predominant. The panel of antibodies to β2-GP-I, An A5, PS/PT, and PE showed a high diagnostic value for RSM. Conclusion. In patients with early RSM, the aPL profile testing including antibodies to CL, β2-GP-I, domain I, antibodies to An A5, PE, and PS/PT improves the accuracy of diagnosis in APS.

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About the authors

Irina V. Menzhinskaya

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: i_menzinskaya@oparina4.ru
Dr.Med.Sci., Leading Researcher at the Laboratory of Clinical Immunology

Ludmila V. Van'ko

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: LVanko@oparina4.ru
Dr.Med.Sci., Professor, Leading Researcher at the Laboratory of Clinical Immunology

Lubov V. Krechetova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: l_krechetova@oparina4.ru
Dr.Med.Sci., Head of the Laboratory of Clinical Immunology

Nana K. Tetruashvili

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: n_tetruashvili@oparina4.ru
Dr.Med.Sci., Head of the 2nd Obstetrics Department of Pathology of Pregnancy

Gennady T. Sukhikh

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: g_sukhikh@oparina4.ru
Dr.Med.Sci., Professor, Academician of the RAS, Director

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