THE EFFECTIVENESS OF TARGETED INTERFERON REPLACEMENT THERAPY IN PATIENTS WITH EXTRAGENITAL ENDOMETRIOSIS


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Abstract

Aim. To compare the effectiveness of extragenital endometriosis (EGE) treatment regimens with and without interferon-alpha-2b (IFN-α2b). Materials and methods. The study comprised 46patients with stage I and II EGE. Twenty-one patients in the study group received standard six months therapy with gonadotropin-releasing hormone agonists (GnRHa) concurrently with IFN-α2b, while 25patients in the control group were administered GnRHa monotherapy. Before surgery and six months after the treatment initiation, the composition of the lymphocyte subpopulations in the peripheral blood was determined by flow cytofluorometry. Results. Compared to the control group, combination therapy of patients with EGE using IFN-α2b was associated with an increase in peripheral blood T and B lymphocyte counts, preservation of NK cell activity with a decrease in their number. Conclusion. The effect ofIFN-α2b as part of combination therapy on the composition of the lymphocyte subpopulations is associated with better immune response toward heterotopic endometrial cells and protective effect against recurrent endometriosis, compared with monotherapy.

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About the authors

Mariya I. YARMOLINSKAYA

D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS; I.I. Mechnikov North-Western State Medical University of Minzdrav of Russia

Email: m.yarmolinskaya@gmail.com
Dr.Med.Sci., Professor of the RAS, Head of the Department of Gynecology and Endocrinology, Head of the Center of Diagnosis and Treatment of Endometriosis, D.O. Ott Research Institute for Obstetrics and Gynecology, Professor at the Department of Obstetrics and Gynecology, I.I. Mechnikov North-Western State Medical University St. Petersburg, Russia

Elena I. DURNEVA

D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS

Email: elenadurnevai303@gmail.com
Ph.D. Student at the Department of Gynecology and Endocrinology St. Petersburg, Russia

Sergey A. SEL'KOV

D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS

Email: selkovsa@mail.ru
Merited Scholar of the Russian Federation, Professor, Head of the Department of Immunology and Intercellular Interactions St. Petersburg, Russia

Sergey V. CHEPANOV

D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS

Email: chepanovsv@gmail.com
Ph.D., Senior Researcher at the Proteomic Immunoregulation Group, Department of Immunology and Intercellular Interactions St. Petersburg, Russia

Alexander V. SELYUTIN

D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS

Email: a_selutin@yahoo.com
Ph.D. (biol.sci.), Senior Researcher at the Immunology Laboratory with AIDS Diagnostics Group, Department of Immunology and Intercellular Interactions St. Petersburg, Russia

Dmitriy I. SOKOLOV

D.O. Ott Research Institute for Obstetrics and Gynecology of the RAS

Email: falcojugger@yandex.ru
Dr.Biol.Sci., Head of the Laboratory of Intercellular Interactions, Department of Immunology and Intercellular Interactions St. Petersburg, Russia

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