Structural and functional state of the lower uterine segment myometrium in postpartum women at risk for infection


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Abstract

Aim. To conduct morphological and immunohistochemical analyses of the structure of the lower uterine segment myometrium in postpartum women at risk for infection. Material and methods. Eighteen tissue samples of the lower uterine segment myometrium from 10 patients at risk of infection (study group) and 8 in the control group were analyzed. The analysis included verif ication and distribution of CD3, CD20, CD68, and actin in myometrial tissue. Results. In patients at risk of infection, the relative area of CD3 in the tissue was 21% greater than in the control group, along with a reduction in the number of CD68 (CD68 area was 19.9% smaller). In the study group, the actin area in the circular myometrium of the lower uterine segment was 5.5% (p <0.05) smaller than in the control group. Conclusion. In pregnant women at risk of infection, an increase in the number of CD3 in the myometrial tissue of the lower uterine segment along with the decrease in the protective function of CD68, and the reduction in the amount of actin in smooth muscle cells by 5.5% (p <0.05) are associated with an impaired postpartum uterine activity.

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About the authors

Sergey V. Barinov

Omsk State Medical University of Minzdrav of the Russia

Email: barinov_omsk@mail.ru
Dr.Med.Sci., Professor, Head of the Department of Obstetrics and Gynecology №2

Yuliya I. Tirskaya

Omsk State Medical University of Minzdrav of the Russia

Email: yulia.tirskaya@yandex.ru
Dr.Med.Sci., Associate Professor, Department of Obstetrics and Gynecology №2

Tat'yana V. Kadtsyna

Omsk State Medical University of Minzdrav of the Russia

Email: tatianavlad@list.ru
Ph.D., Associate Professor, Department of Obstetrics and Gynecology №2

Oksana V. Lazareva

Omsk State Medical University of Minzdrav of the Russia

Email: lazow@mail.ru
Ph.D., Associate Professor, Department of Obstetrics and Gynecology №2

Irina V. Medyannikova

Omsk State Medical University of Minzdrav of the Russia

Email: mediren@mail.ru
Dr.Med.Sci., Associate Professor, Department of Obstetrics and Gynecology №2

Yurij I. Chulovsky

Omsk State Medical University of Minzdrav of the Russia

Email: akusheromsk@rambler.ru
Ph.D., Associate Professor, Department of Obstetrics and Gynecology №2

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