Current trends in the search for endometrial receptivity markers: from individual parameters to a comprehensive approach


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Abstract

Implantation, a process that reflects the blastocyst-endometrium interaction, is a key step to achieve desired pregnancy. Many studies of endometrial receptivity have been conducted in recent decades; however, a universal marker that is able to predict successful implantation has not yet been established. Analysis of the data available in the literature may lead to the conclusion that none of the existing ultrasound-based approaches, including the assessment of the endometrial thickness, pattern, and volume, and the features of endometrial vascularization, provides any opportunity to fully assess the receptive ability of the endometrium. Molecular studies of endometrial receptivity also cannot be recognized to be highly effective at the moment. In this connection, it can be noted that it is important to avoid searching for a single receptivity marker, preferring to develop the diagnostic panels that combine the most effective markers, the complex analysis of which will have a higher diagnostic value. The review includes data from the foreign and Russian articles published in the SCOPUS, Web of Science, MEDLINE, Cochrane Library, Embase, Global Health, CyberLeninka, and PubMed databases over the past 10 years Conclusion. Considering a set of indicators that take into account thickness, volume, echo structure, blood flow, morphological features, and molecular markers that characterize these parameters in the endometrium, it seems possible to approximate to the understanding of complex, multicomponent processes in the receptive endometrium.

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About the authors

Alina A. Dovgan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: lina.dovgan@gmail.com
Postgraduate Student, Department of Assistive Technologies in Infertility Treatment

Marina M. Ziganshina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: mmz@mail.ru
PhD., Leading Research Associate, Laboratory of Clinical Immunology

Nataliya V. Dolgushina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department

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