Possibilities of predicting the outcomes of assisted reproductive technology programs in patients with ovarian endometrioid cysts on the basis of the metabolic profile of follicular fluid


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

At present, the problem of restoring fertility in patients with ovarian endometrioid cysts is the focus of attention for physicians around the world. Despite intensive research, the search for biomarkers that affect the effectiveness of in vitro fertilization programs in this patient group is not progressing well enough. Follicular fluid is a biological medium that has a direct impact on oocyte growth and maturation, and subsequently on the process of fertilization. The search for biomarkers that can be further used as prognostic factors for embryo development and outcomes of in vitro fertilization programs is an extremely important area. This literature review presents data on changes in the metabolomic profile of follicular fluid in patients with ovarian endometrioid cysts and discusses the current potentials of metabolomics in order to enhance the efficiency of infertility treatment and to optimize the embryological stage in women with endometriomas. Conclusion. Based on the findings, further investigations to study the metabolomic profile of follicular fluid is relevant and may lead to the development of new prognostic strategies, as well as to the elaboration of algorithms for the management of patients with this pathology in the assisted reproductive technology programs.

Full Text

Restricted Access

About the authors

Inna G. Nikolenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nikolenkoinna@mail.ru
Postdoc of IVF Department

Veronika Yu. Smolnikova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: veronika.smolnikova@mail.ru
PhD, leading researcher, Department of Assistive Technologies in Infertility Treatment

Vitaliy V. Chagovets

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: vvchagovets@gmail.com
Ph.D. in Physical and Mathematical Sciences, Senior researcher of the Laboratory of Proteomics and Metobolomics of the Human Reproduction

References

  1. Burney R.O., Giudice L.C. Pathogenesis and pathophysiology of endometriosis. Fertil. Steril. 2012; 98(3): 511-9. https://dx.doi.org/10.1016/ j.fertnstert.2012.06.029.
  2. Vercellini P., Vigano P., Somigliana E., Fedele L. Endometriosis: pathogenesis and treatment. Nat. Rev. Endocrinol. 2014; 10(5): 261-75. https:// dx.doi. org/10.1038/nrendo.2013.255.
  3. Адамян Л.В., Андреева Е.Н., Аполихина И.А., Беженарь В.Ф., Геворкян М.А., Гус А.И., Демидов В.Н., Калинина Е.А., Леваков С.А., Марченко Л.А., Попов А.А., Сонова М.М., Хашукоева А.З., Чернуха Г.Е., Яроцкая Е.Л. Эндометриоз: диагностика, лечение и реабилитация. Федеральные клинические рекомендации по ведению больных. М.; 2013. 65 c. [Adamyan L.V. et al. Endometriosis: diagnosis, treatment and rehabilitation. 2013. 65 p. (in Russian)].
  4. Giacomini E., Sanchez A.M., Sarais V., Beitawi S., Candiani M., Vigano P. Characteristics of follicular fluid in ovaries with endometriomas. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017; 209: 34-8. https://dx.doi.org/10.1016/j. ejogrb.2016.01.032.
  5. Guo N., Zhang X.M., Shi W., Tong X.H., Iqbal F. Oocyte quality is decreased in women with minimal or mild endometriosis. Sci. Rep. 2015; 5: 10779. https:// dx.doi.org/10.1038/srep10779.
  6. Sanchez A.M., Vigano P., Quattrone F., Pagliardini L., Papaleo E., Candiani M. et al. The WNT/P-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: endometriosis as a paradigm for a dysregulated apoptosis pathway. Fertil. Steril. 2014; 101(6): 1688-96. https:// dx.doi.org/10.1016/j.fertnstert.2014.02.040.
  7. Sanchez A.M., Vigano P., Somigliana E., Panina-Bordignon P., Vercellini P., Candiani M. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum. Reprod. Update. 2014; 20(2): 217-30. https://dx.doi.org/10.1093/humupd/dmt053.
  8. Лисица А.В., Пономаренко Е.А., Лохов П.Г., Арчаков А.И. Постгеномная медицина: альтернатива биомаркерам. Вестник Российской Академии медицинских наук. 2016; 71(3): 255-60. [Lisitsa A.V., Ponomarenko E.A., Lokhov P.G., Archakov A.I. Postgenomic medicine: an alternative to biomarkers. Bulletin of the Russian Academy of medical Sciences. 2016; 3: 25560. (in Russian)]. https://dx.doi.org/10.15690/vramn647.
  9. Cordeiro F.B., Cataldi Th.R., da Costa L., de Souza B.Z., Fraietta R., Labate C. et al. Metabolomic profiling in follicular fluid of patients with infertility-related deep endometriosis. Metabolomics. 2017; 13(10): 120. https:// dx.doi.org/10.1007/s11306-017-1262-3.
  10. Bulun S.E. Ovarian endometriosis: the nemesis of eggs. Fertil. Steril. 2014; 101(4): 938-9. https://dx.doi.org/10.1016/j.fertnstert.2014.01.044.
  11. Harb H.M., Gallos I.D., Chu J., Harb M., Coomarasamy A. The effect of endometriosis on in vitro fertilisation outcome: a systematic review and metaanalysis. BJOG. 2013; 120(11): 1308-20. https://dx.doi.org/10.1111/1471-0528.12366.
  12. Benschop L., Farquhar C., van der Poel N., Heineman M.J. Interventions for women with endometrioma prior to assisted reproductive technology. Cochrane Database Syst. Rev. 2010; (11): CD008571. https://doi.org/10.1002/14651858. CD008571.pub2.
  13. Lee K.H., Kim C.H., Lee Y.J., Kim S.H., Chae H.D., Kang B.M. Surgical resection or aspiration with ethanol sclerotherapy of endometrioma before in vitro fertilization in infertilie women with endometrioma. Obstet. Gynecol. Sci. 2014; 57(4): 297-303. https://doi.org/10.5468/ogs.2014.57A297.
  14. Benaglia L., Somigliana E., Vighi V., Ragni G., Vercellini P., Fedele L. Rate of severe ovarian damage following surgery for endometriomas. Hum. Reprod. 2010; 25(3): 678-82. https://dx.doi.org/10.1093/humrep/dep464.
  15. Yang C., Geng Y., Li Y., Chen C., Gao Y. Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis. Reprod. Biomed. Online. 2015; 31(1): 9-19. https://dx.doi.org/ 10.1016/ j.rbmo.2015.03.005.
  16. Hamdan M., Dunselman G., Li T.C., Cheong Y. The impact of endometrioma on IVF/ICSI outcomes: a systematic review and meta-analysis. Hum. Reprod. Update. 2015; 21(6): 809-25. https://dx.doi.org/10.1093/humupd/dmv035.
  17. Sanchez A.M., Vigano P., Somigliana E., Panina-Bordignon P., Vercellini P., Candiani M. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum. Reprod. Update. 2014; 20(2): 217-30. https://dx.doi.org/10.1093/humupd/dmt05.
  18. Sanchez A.M., Somigliana E., Vercellini P., Pagliardini L., Candiani M., Vigano P. Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development: from molecular alterations to clinical impact. J. Steroid Biochem. Mol. Biol. 2016; 155(Pt. A): 35-46. https://dx.doi.org/10.1016/j. jsbmb.2015.07.023.
  19. Singh A.K., Dutta M., Chattopadhyay R., Chakravarty B., Chaudhury K. Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis. J. Assist. Reprod. Genet. 2016; 33(10): 1363-72. https://dx.doi. org/10.1007/s10815-016-0782-5.
  20. Wang Y., Liu S., Hu Y., Li P., Wan J.B. Current state ofthe art ofmass spectrometry-based metabolomics studies: a review focusing on wide coverage, high throughput and easy identification. RSC Adv. 2015; 96(5): 78728-37. https://dx.doi.org/10.1039/ C5RA14058G.
  21. Kuehnbaum N.L., Britz-McKibbin P. New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era. Chem. Rev. 2013; 113(4): 2437-68. https://dx.doi.org/10.1021/ cr300484s.
  22. Emwas A.H., Roy R., McKay R.T., Tenori L., Saccenti E., Gowda GAN. NMR spectroscopy for metabolomics research. Metabolites. 2019: 9(7): 123. https:// dx.doi.org/10.3390/metabo9070123.
  23. Karaer A., Tuncay G., Mumcu A., Dogan B. Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization. Syst. Biol. Reprod. Med. 2019; 65(1): 39-47. https://dx.doi.org/10.1080/1939 6368.2018.1478469.
  24. Xia L., Zhao X., Sun Y., Hong Y., Gao Y., Hu S. Metabolomic profiling of human follicular fluid from patients with repeated failure of in vitro fertilization using gas chromatography/mass spectrometry. Int. J. Clin. Exp. Pathol. 2014; 7(10): 7220-9.
  25. Santonastaso M., Pucciarelli A., Costantini S., Caprio F., Sorice A., Capone F. et al. Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients. Mol. Biosyst. 2017; 13(6): 1213-22. https://dx.doi. org/10.1039/c7mb00181a.
  26. Cordeiro F.B., Cataldi T.R., Perkel K.J., do Vale Teixeira da Costa L., Rochetti R.C., Stevanato J. et al. Lipidomics analysis of follicular fluid by ESI-MS reveals potential biomarkers for ovarian endometriosis. Assist. Reprod. Genet. 2015; 32(12): 1817-25. https://dx.doi.org/10.1007/s10815-015-0592-1.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies