AGE AND BODY MASS INDEX AS FACTORS OF FEMALE INFERTILITY AND NEGATIVE RESULTS OF ASSISTED REPRODUCTIVE TECHNOLOGIES

To improve the effective«ess of assisted reproductive tech«ologies is a key problem i« modern medici«e. Therapeutic approaches to reducmg the likelihood of «otgett'mgpreg«a«t are i«evitably associated with mfertility-related risk factors. Wome« with good reproductive health mostly become mothers «aturally, apart from bei«g influenced by the malefactor or resorti«g to medical decisio«s through perso«al reaso«s. Amo«g the sta«dard risk factors that lead to a decrease i« the effective«ess of assisted reproductive tech«ologies, there are obesity a«d late reproductive age. The paper considers the mecha«isms for the «egative effects of these features of the a«am«esis a«d the ways to reduce/overcome their harmful effects o« preg«a«cy. A« a«alysis of i«formatio« sources has identified the possibilities of increasing the effectiveness of the onset a«d preservatio« of induced preg«a«cy in the prese«ce of the above risk factors. It has bee« fou«d that it is «ecessary to orga«ize a comprehe«sive preparation of a womans health before reproductive intervention in order to «ormalize weight a«d the hormo«e backgrou«d. O«ly a cha«ge in lifestyle a«d consolidation of «ew behavior ca« sig«ifica«tly reduce the «egative impact of obesity o« a womans reproductive health. Treatment should be performed taki«g into accou«t co«comita«t diseases, in particular diabetes mellitus, polycystic ovary syndrome, etc. The successes of pharmacological treatment for obesity i« reduci«g the level of i«flue«ce of i«fertility a«d i« i«creasi«g the effective«ess of assisted reproductive tech«ologies are a«alyzed separately. Conclusion. It has been found that there are very few drugs that can be used to correct weight during pregnancy when planning due to side effects. Before planning a pregnancy at late reproductive age, there is a need for exhaustive analysis of the female reproductive system, including an evaluation of the ability to ovulate and the state of the endometrium. Exogenous hormonal background correction must be done. The negative effect of obesity or late reproductive age depends on many individual characteristics of the patient's history. Therefore, whether there is a prevalence of the influence of one or another factor in their combination remains unresolved and causes discussion.

obesity, body mass index, late reproductive age, assisted reproductive technologies