Reactive oxygen species and components of the antioxidant defense system as markers for prediction of embryo quality in married couples with different infertility types


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Abstract

The review presents an update on the effect of reactive oxygen species (ROS) and components of the antioxidant defense system on gamete quality in married couples with infertility, as well as the possibility of using antioxidants to increase the probability of obtaining good morphology embryos. It considers the possibility ofdetermining the follicular fluid, ejaculate, and blood levels of ROS and antioxidants as embryo quality markers in infertility of various origins. The review includes data from foreign and Russian articles published on this topic in Scopus, Web of Science, MEDLINE, Cochrane Library, EMBASE, Global Health, CyberLeninka, and Pubmed over the past 10 years. Follicular fluid and ejaculate are unique objects of a study, since they carry information about the developmental features of male and female gametes and their investigation is likely to determine the levels of oxidative stress parameters in the ejaculate and follicular fluid and also to reveal a correlation of these indicators with the peripheral blood of the spouses. These studies will be able to introduce an additional method to assess the cellular material and to predict the quality of the resulting embryo, which, in turn, will improve the outcomes of ART programs for married couples with different infertility types. Estimation of the levels of oxidative stress parameters in the follicular fluid, ejaculate, and peripheral blood of both spouses according to the cause of infertility is a promising area that will be able to predict the quality of the resulting material. In addition, the use of antioxidant therapy in the married couples with severe oxidative stress will reduce the likelihood of obtaining poor quality embryos. Conclusion. Evidence-based data on oxidative stress parameters in the follicular fluid, ejaculate, and peripheral blood may make it possible to develop an additional non-invasve method for assessing the quality of embryos and to elaborate an algorithm for the individual management of married couples with severe oxidative stress in ART programs.

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About the authors

Veronika Yu. Smolnikova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: veronika.smolnikova@mail.ru
PhD, leading researcher, Department of Assistive Technologies in Infertility Treatment

Diana S. Agadzhanyan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: agadzhanyand@inbox.ru
post-graduate student, Department of assistive technologies in infertility treatment

Alexey M. Krasnyi

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: alexred@list.ru
PhD in Biology, Head of the Laboratory of Cytology

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