PREDICTION OF ART OUTCOMES AND TREATMENT OF CHOICE IN PCOS PATIENTS


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Abstract

Objective. To study the clinical and anamnestic factors for prediction of Assisted Reproductive Technology (ART) outcomes and determine the treatment of choice in polycystic ovary syndrome (PCOS) patients. Materials and methods. A retrospective study included 311 patients with PCOS who underwent fertility treatment using ART. Embryo transfer was performed in stimulated cycle in 59 patients (group I). «Freeze all» approach was performed in 98patients (group II). Frozen embryo transfer (FET) was performed in 154 patients (group III), 35 of them had PgT-A with NGS. Results. The clinical pregnancy rate was signif icantly higher in FET group (70.6%) compared to the transfer in the stimulated cycle (52.5%, p=0.013). Transfer of euploid embryo resulted in highest clinical pregnancy rate (82.9%). Miscarriage rate was lowest in FET after PgT-A (OR 0.428; 95% CI 0.19-0.97). Hyperandrogenism, high AMH levels and overweight/obesity turned out to have negative effect on embryological and clinical ART outcomes. Conclusion. FET is accompanied by a higher pregnancy rate and a lower risk of pregnancy loss in PCOS patients. PGT-A helps to maximize the effectiveness of ART programs with a minimize the risk of miscarriage.

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About the authors

Yulia A. Koloda

Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation

Email: julkol@yandex.ru
125993, Russia, Moscow, Barrikadnaya str., 2/1-1

Natalia M. Podzolkova

Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation

125993, Russia, Moscow, Barrikadnaya str., 2/1-1

Yulia G. Petrichenko

Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation

125993, Russia, Moscow, Barrikadnaya str., 2/1-1

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