Identity of preeclampsia and metabolic syndrome clinical manifestations: searching for substantiation


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Abstract

Aim. To investigate clinical and laboratory parameters in pregnant women with preeclampsia (PE) who have and do not have metabolic syndrome (MS) to identify common clinical and pathogenetic patterns. Materials and methods. The study included 89 women with PE and high-risk factors (group I), 50 women with PE and MS (group II), 32 women with MS without PE (group III), and 30 women with a healthy pregnancy (group IV, control group). The study participants underwent comprehensive clinical and laboratory examinations. Results. Compared to controls, patients with PE without somatic comorbidities and PE with MS were more likely to have abnormal 24-h BP patterns (non-dipper, night-picker), episodes of gestational sleep apnea, insomnia, increased visceral adipose tissue, which are typical for MS outside of pregnancy. The laboratory parallels between MS and PE were confirmed by similar changes in metabolic and hormonal parameters, markers of proinflammatory andprothrombotic states, angiogenesis, and endothelial dysfunction. Conclusion. The identity of clinical and pathogenetic patterns of MS and PE is based on pathological insulin resistance, hyperinsulinemia, and associated atherogenic dyslipidemias, hyperleptinemia, proinflammatory and immune-metabolic disorders, oxidative stress, hyperuricemia, prothrombotic and hyper-sympathetic states which account for similar clinical features.

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About the authors

Igor S. Lipatov

Samara State Medical University, Ministry of Health of Russia

Email: i.lipatoff20l2@yandex.ru
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No I

Yurii V. Tezikov

Samara State Medical University, Ministry of Health of Russia

Email: yra.75@inbox.ru
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology No I

Amir R. Azamatov

Samara State Medical University, Ministry of Health of Russia

Email: azamatov.amir@yandex.ru
Resident at the Department of Obstetrics and Gynecology No I

Roman G. Shmakov

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: mdshmakov@mail.ru
Dr. Med. Sci., Professor of the RAS, Director of the Institute of Obstetrics

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