Predictive value of autoimmune markers in assisted reproductive technologies


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

To improve the effectiveness of assisted reproductive technologies (ART), it is important to investigate possible risk factors, including autoantibodies of different specificity, associated with ARTfailure. Aim. To investigate autoantibody profiles and their value as predictors of ART outcomes in infertile women. Materials and methods. The study included 65 infertile patients before ovarian stimulation in ART and 48 fertile women. Using an enzyme-linked immunosorbent assay (ELISA), they were tested for serum antiphospholipid antibodies (aPL), antibodies to human chorionic gonadotropin, progesterone (aPG), and estradiol (aE). Results. Among infertile patients, 15.4% had aPLs, and 47.7-56.9% had antibodies (M, G) to hormones (P40.0001). The implantation rate in patients seropositive for IgM aPG and aE was lower (7.1%; 6.25%) than in seronegative (37.3%; 38.8%) (P <0.05). Testing for these antibodies has shown high sensitivity and specificity with the AUC of0.722 and 0.725 and the test accuracy of 71.4%. Conclusion. In infertile patients, serum autoantibodies to steroid hormones are risk factors for ART failure and may have a role in predicting outcomes.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Irina Menzhinskaya

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: i_menzinskaya@oparina4.ru
Dr. Med. Sci., Leading Researcher at the Laboratory of Clinical Immunology

Elizaveta Kraevaya

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_kraevaya@oparina4.ru
Researcher at the Department of Assisted Technologies for the Treatment of Infertility

Elena Kalinina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the Department of Assisted Technologies for the Treatment of Infertility, Scientific Secretary of the Dissertation Council

Ludmila Vanko

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: lvanko@oparina4.ru
Dr. Med. Sci., Professor, Leading Researcher at the Laboratory of Clinical Immunology

Nataliya Dolgushina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
Dr. Med. Sci., Deputy Director - Head of the Department of Research Administration

Әдебиет тізімі

  1. Deroux A., Dumestre-Perard C., Dunand-Faure C., Bouillet L., Hoffmann P. Female infertility and serum auto-antibodies: a systematic review. Clin. Rev. Allergy Immunol. 2017; 53(1): 78-86. https://dx.doi.org/10.1007/ s12016-016-8586-z.
  2. Корсак В.С., Смирнова А.А., Шурыгина О.В. ВРТ в России. Отчет за 2016 г. Проблемы репродукции. 2018; 24(6): 8-21.
  3. Вартанян Э.В., Мартышкина Е.Ю., Цатурова К.А. Роль сочетанной патологии в неудачных протоколах ЭКО. Акушерство, гинекология и репродукция. 2011; 5(4): 40-3.
  4. Кривонос М.И., Зайнулина М.С., Чепанов С.В., Селютин А.В., Сельков С.А., Мысик О.Л. Клинико-иммунологические аспекты ведения женщин с неудачами ВРТ. Журнал акушерства и женских болезней. 2014; 63(5): 89-95.
  5. Simon A., Laufer N. Repeated implantation failure: clinical approach. Fertil. Steril. 2012; 97(5): 1039-43. https://dx.doi.org/10.1016/j.fertnstert.2012.03.010.
  6. Revel A. Defective endometrial receptivity. Fertil. Steril. 2012; 97(5): 1028-32. https://dx.doi.org/10.1016/j.fertnstert.2012.03.039.
  7. Chen X., Mo M.L., Huang C.Y., Diao L.H., Li G.G., Li Y.Y. et al. Association of serum autoantibodies with pregnancy outcome of patients undergoing first IVF/ ICSI treatment: a prospective cohort study. J. Reprod. Immunol. 2017; 122: 14-20. https://dx.doi.org/10.1016/j.jri.2017.08.002.
  8. Haller-Kikkatalo K., Salumets A., Uibo R. Review on autoimmune reactions in female infertility: antibodies to follicle stimulating hormone. Clin. Dev. Immunol. 2012; 2012: 762541. https://dx.doi.org/10.1155/2012/762541.
  9. Менжинская И.В., Ванько Л.В. Ассоциация антител к гонадотропинам и женским половым гормонам с нарушениями репродуктивной функции. Акушерство и гинекология. 2017; 9: 20-7. https://dx.doi.org/ 10.18565/ aig.2017.9.20-7.
  10. Itsekson A.M., Seidman D.S., Zolti M., Alesker M., Carp H.J. Steroid hormone hypersensitivity: clinical presentation and management. Fertil. Steril. 2011; 95(8): 2571-3. https://dx.doi.org/ 10.1016/j.fertnstert.2011.05.025.
  11. Untersmayr E., Jensen A.N., Walch K. Sex hormone allergy: clinical aspects, causes and therapeutic strategies - update and secondary publication. World Allergy Organ. J. 2017; 10(1): 45. https://dx.doi.org/10.1186/ s40413-017-0176-x.
  12. Foer D., Buchheit K.M. Presentation and natural history of progestogen hypersensitivity. Ann. Allergy Asthma Immunol. 2019; 122(2): 156-9. https:// dx.doi.org/10.1016/j.anai.2018.10.023.
  13. Roby R.R., Richardson R.H., Vojdani A. Hormone allergy. Am. J. Reprod. Immunol. 2006; 55(4): 307-13. https://dx.doi.org/10.1111/ j.1600-0897.2006.00373.x.
  14. Сидельникова В.М. Подготовка и ведение беременности у женщин с привычным невынашиванием: методическое пособие и клинические протоколы. М.: МЕДпресс-информ; 2010. 224 с.
  15. Ciampaglia W., Cognigni G.E. Clinical use of progesterone in infertility and assisted reproduction. Acta Obstet. Gynecol. Scand. 2015; 94(Suppl. 161): 17-27. https://dx.doi.org/10.1111/aogs.12770.
  16. Gupta A., Goenka D., Goenka M.L. Progesterone hypersensitivity: a challenge for luteal support. J. Hum. Reprod. Sci. 2018; 11(1): 79-81. https://dx.doi. org/10.4103/jhrs.JHRS_116_17.
  17. Itsekson A.M., Soriano D., Zolti M., Seidman D.S., Carp H.J.A. Intradermal sex hormone desensitization for relief of premenstrual symptoms may improve the obstetric outcome of women with recurrent pregnancy loss. Gynecol. Endocrinol. 2013; 29(2): 169-72. https://dx.doi.org/10.3109/ 09513590.2012.730582.
  18. Ellaithy M.I., Fathi H.M., Farres M.N., Taha M.S. Skin test reactivity to female sex hormones in women with primary unexplained recurrent pregnancy loss. J. Reprod. Immunol. 2013; 99(1-2): 17-23. https://dx.doi.org/10.1016/ j.jri.2013.04.006.
  19. Foer D., Buchheit K.M., Gargiulo A.R., Lynch D.M., Castells M., Wickner P.G. Progestogen hypersensitivity in 24 cases: diagnosis, management, and proposed renaming and classification. J. Allergy Clin. Immunol. Pract. 2016; 4(4): 723-9. https://dx.doi.org/10.1016/j.jaip.2016.03.003.
  20. Prieto-Garcia A., Sloane D.E., Gargiulo A.R., Feldweg A.M., Castells M. Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil. Steril. 2011; 95(3): 1121. e9-3. https://dx.doi.org/10.1016/j.fertnstert.2010.10.038.
  21. Менжинская И.В., Безнощенко О.С., Сароян Т.Т., Корнеева И.Е., Ванько Л.В., Сухих Г.Т. Антитела к гормонам репродуктивной системы как возможный фактор риска неблагоприятного исхода в циклах экстракорпорального оплодотворения. Акушерство и гинекология. 2012; 2: 42-5.
  22. Gardner D.K., Weissman A., Howles C.M., Shoham Z., eds. Textbook of assisted reproductive technologies: laboratory and clinical perspectives. 3rd ed. London: Informa Healthcare; 2009. 944p.
  23. Менжинская И.В., Кашенцева М.М., Ванько Л.В., Сухих Г.Т. Иммунохимические свойства аутоантител к хорионическому гонадотропину у женщин с невынашиванием беременности. Иммунология. 2015; 36(1): 30-5.
  24. Менжинская И.В., Гладкова К.А., Сидельникова В.М., Сухих Г.Т. Антипрогестероновые антитела в клинике привычной потери беременности. Иммунология. 2008; 29(1): 34-7.
  25. Pennell L.M., Galligan C.L., Fish E.N. Sex affects immunity. J. Autoimmun. 2012; 38(2-3): J282-91. https://dx.doi.org/10.1016/j.jaut.2011.11.013.
  26. Гладкова К.А., Менжинская И.В., Сухих Г.Т., Сидельникова В.М. Роль сенсибилизации к прогестерону в клинике привычного невынашивания беременности. Проблемы репродукции. 2007; 13(6): 95-8.
  27. Zou S.H., Yang Z.Z., Zhang P., Song D.P., Li B., Wu R.Y. et al. Autoimmune disorders affect the in vitro fertilization outcome in infertile women. Zhonghua Nan Ke Xue. 2008; 14(4): 343-6.
  28. Muller V., Ob’edkova K., Krikheli I., Kogan I., Fedorova I., Lesik E. et al. Successful pregnancy outcome in women with recurrent IVF failure and anti-hCG autoimmunity: a report of three cases. Case Reports Immunol. 2016; 2016: 4391537. https://dx.doi.org/10.1155/2016/4391537.
  29. Di Renzo G.C., Giardina I., Clerici G., Brillo E., Gerli S. Progesterone in normal and pathological pregnancy. Horm. Mol. Biol. Clin. Investig. 2016; 27(1): 35-48. https://dx.doi.org/10.1515/hmbci-2016-0038.
  30. Halasz M., Szekeres-Bartho J. The role of progesterone in implantation and trophoblast invasion. J. Reprod. Immunol. 2013; 97(1): 43-50. https:// dx.doi.org/10.1016/j.jri.2012.10.011.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Bionika Media, 2021