Predictive value of autoimmune markers in assisted reproductive technologies


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Abstract

To improve the effectiveness of assisted reproductive technologies (ART), it is important to investigate possible risk factors, including autoantibodies of different specificity, associated with ARTfailure. Aim. To investigate autoantibody profiles and their value as predictors of ART outcomes in infertile women. Materials and methods. The study included 65 infertile patients before ovarian stimulation in ART and 48 fertile women. Using an enzyme-linked immunosorbent assay (ELISA), they were tested for serum antiphospholipid antibodies (aPL), antibodies to human chorionic gonadotropin, progesterone (aPG), and estradiol (aE). Results. Among infertile patients, 15.4% had aPLs, and 47.7-56.9% had antibodies (M, G) to hormones (P40.0001). The implantation rate in patients seropositive for IgM aPG and aE was lower (7.1%; 6.25%) than in seronegative (37.3%; 38.8%) (P <0.05). Testing for these antibodies has shown high sensitivity and specificity with the AUC of0.722 and 0.725 and the test accuracy of 71.4%. Conclusion. In infertile patients, serum autoantibodies to steroid hormones are risk factors for ART failure and may have a role in predicting outcomes.

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About the authors

Irina V. Menzhinskaya

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: i_menzinskaya@oparina4.ru
Dr. Med. Sci., Leading Researcher at the Laboratory of Clinical Immunology

Elizaveta E. Kraevaya

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_kraevaya@oparina4.ru
Researcher at the Department of Assisted Technologies for the Treatment of Infertility

Elena A. Kalinina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the Department of Assisted Technologies for the Treatment of Infertility, Scientific Secretary of the Dissertation Council

Ludmila V. Vanko

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: lvanko@oparina4.ru
Dr. Med. Sci., Professor, Leading Researcher at the Laboratory of Clinical Immunology

Nataliya V. Dolgushina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
Dr. Med. Sci., Deputy Director - Head of the Department of Research Administration

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