The role of myo-inositol in preparing women for assisted reproductive technologies


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Objective. To evaluate the effectiveness of administering the myo-inositol and folic acid complex on the quality of embryos and the pregnancy rate during preconception preparation for in vitro fertilization (IVF) in patients with infertility. Materials and methods. The study included 92 infertile patients planning to undergo IVF, among them 46 women (group I) received the complex of myo-inositol (MI) at a dose of4000 mg and folic acid (FA) at a dose of400 mcg (Fertina, Orion Pharma, Finland) per day for 12 weeks, and 46 women (group II) received only 400 mcg of folic acid per day. The research was performed in accordance with the Order of the Russian Ministry of Health No. 107n dated 30.08.2012. The criteria for evaluating the effectiveness of the complex were the facts of biochemical pregnancy based on the analysis of hCG and clinical pregnancy according to the ultrasound data. Results. The women who took the MI/FA complex before the IVF protocol, in comparison with the women taking only FA, showed the following results: a shorter duration of ovarian stimulation, 9 (9-10) vs. 11 (10-11) days, p=0.04; a lower total dose of gonadotropins, 1470 (1425-1445) vs. 1990 (1775-2150) IU/ml, p=0.01; a larger number of oocytes at MIIstage, 9 (4-17) vs. 6 (3-15) oocytes, p=0.03, respectively. The number of biochemical pregnancies was 19 (68%) vs. 10 (42%), p=0.05, and clinical pregnancies were noted in 15 (53%) vs. 8 (33%) cases, p=0.14, respectively. Conclusion. Administration of the complex MI and FA for three months before IVF has a positive effect on the process of oocyte maturation and pregnancy rate.

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作者简介

Elena Kvashnina

JSC Rehabilitation Center for Reproductive Disorders "Partus"

Email: doctor.kvashnina@gmail.com
PhD, leading reproductive specialist

Tatyana Gvozdikova

LLC "ECO Center", Lipetsk

Email: slukina.t@gmail.com
PhD, reproductologist

Alena Druzhinina

LLC Medica-Mente, Moscow

Email: dr.druzhinina@gmail.com
gynecologist

Irina Masterova

LLC "ECO Center", Petrozavodsk

Email: irramasterova@gmail.com
gynecologist, reproductologist, chief medical officer

Svetlana Murunova

LLC "ECO Center", Simferopol

Email: svetamurunova@mail.ru
obstetrician-gynecologist

Tatiana Plotavskaya

LLC "ECO Center", Smolensk

Email: rakitskaya_t@mail.ru
obstetrician-gynecologist, reproductologist

Maksim Tutakov

JSC Rehabilitation Center for Reproductive Disorders "Partus"

Email: tutakov@ivf-partus.ru
leading embryologist

Svetlana Pavlyuchenkova

LLC Medica-Mente, Moscow

Email: emdir@sweetgroup.ru
PhD, Director of embryology

Natalya Shilova

LLC Reprohelp, Moscow

Email: nvshilova@gmail.com
Сand. of Мed. Sci., Director

Galina Dikke

Academy of Medical Education named after F.I. Inozemtsev

Email: galadikke@yandex.ru
Dr. Med. Sci., associate professor, Professor of the Department of obstetrics and gynecology with a course of reproductive medicine

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