ROLE OF OXIDATIVE STRESS IN THE DEVELOPMENT OF GYNECOLOGICAL DISEASES


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Abstract

Oxidative stress is an imbalance between the prooxidants and components of the antioxidant defense system, which causes changes in metabolism and energy balance in the body: the cells get damaged; pathological changes occur in human tissues and organs. The effect of prooxidants leads to oxidation of nucleic acids and to peroxidation of lipids, cell membrane shells, and protein structures. According to the modern concepts, carbonyl stress plays a major damaging role. The above changes contribute to the development of many diseases, for example, cardiovascular system diseases can affect the normal functioning of the brain and lead to various pregnancy complications, provoke and aggravate the course of different gynecological diseases. Despite the results of studies that indicate the role of various markers of oxidative stress in determining this pathological condition, specific indicators that could be used in routine practice have not been identified today. Antioxidant enzymes play a main role in antioxidant defense. However, to date, there is no clear opinion about the elimination of the consequences of oxidative stress. Numerous studies are being conducted to figure out the methods that might reduce the likelihood of developing this pathological process.

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About the authors

Irina Yu. Ilyina

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: iliyina@mail.ru
Dr. Med. Sci., professor 117513, Russia, Moscow, Ostrovitianov str., 1/9

Yuliya E. Dobrokhotova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: pr.dobrohotova@mail.ru
Dr. Med. Sci., professor 117513, Russia, Moscow, Ostrovitianov str., 1/9

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