CLINICAL USE OF DRUGS CONTAINING SERTACONAZOLE IN THE TREATMENT OF VULVOVAGINAL CANDIDIASIS


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Abstract

Vulvovaginal candidiasis (VVC) is one of the problems of modern health care which reduces the quality of life of women. Candida albicans is a representative of the normal microflora of the vagina. Under certain conditions it affects the mucous membrane and forms an aggressive biofilm. Recurrent VVC is detected in 20-50% of patients. The search for effective, easy-to-use, affordable medical preparations is a major clinical challenge for a doctor. This article provides an overview of such a condition as VVC, aspects of its diagnosis, treatment, and prevention, as well as a clinical example and a description of drugs containing sertaconazole. Conclusion. Complex therapy provides a comprehensive approach to the treatment of VVC in three stages: primary hygiene (Zalagel Intim gel), treatment (vaginal Zalain suppository, Zalain cream), intimate hygiene (Zalagel Intim gel). The advantages of applying vaginal Zalain suppositories are their single use, the absence of a systemic effect and a wide spectrum of action (it acts on both Candida albicans and Candida non-albicans), the absence of cross-resistance of fungi to the drug, absence of effects on the normal vaginal microflora (lactobacilli), concomitant antibacterial activity (on the coccal flora) and anti-inflammatory effect. A single intravaginal administration of a suppository at a dose of300 mg is a complete course of treatment in exacerbation of VVC.

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About the authors

Inna A. Apolikhina

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: i_apolikhina@oparina4.ru
MD, Head of the Department of Aesthetic Gynecology and Rehabilitation; Professor of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education 117997, Russia, Moscow, Oparina str., 4

Elena A. Gorbunova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: lifehelen@gmail.com
obstetrician-gynecologist, physiotherapist of the Department of Aesthetic Gynecology and Rehabilitation 117997, Russia, Moscow, Oparina str., 4

Darya A. Malyshkina

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: nidsumi@mail.ru
graduate student 117997, Russia, Moscow, Oparina str., 4

Andrey E. Donnikov

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: donnikov@dna-technology.ru
PhD, Head of the Laboratory of Molecular Genetic Methods 117997, Russia, Moscow, Oparina str., 4

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