Clinical course of pregnancy, childbirth and perinatal outcomes in women with intrahepatic cholestasis of pregnancy
- Authors: Chemortan M.I1, Sagaidak I.V1
-
Affiliations:
- Nicolae Testemianu Moldova State University of Medicine and Pharmacy (USMF)
- Issue: No 5 (2021)
- Pages: 94-99
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249175
- DOI: https://doi.org/10.18565/aig.2021.5.94-99
- ID: 249175
Cite item
Open Access
Access granted
Abstract
Background. The risk of adverse perinatal outcomes is significantly high in pregnant women with intrahepatic cholestasis of pregnancy. Aim. Assessment and analysis of the characteristics of the course of pregnancy and delivery, the incidence and structure of perinatal morbidity among women with intrahepatic cholestasis of pregnancy. Materials and methods. The study was based on a retrospective case-control study, which included 205 women aged 17-43 years. They were divided into 2 groups depending on the complications of intrahepatic cholestasis of pregnancy Statistical data were processed using IBM SPSS Statistics V21.0 software. Results. The women, whose pregnancies were complicated by intrahepatic cholestasis of pregnancy, had an increased incidence of iron deficiency anemia, cesarean sections and needed longer hospital stay. The assessment of perinatal outcomes showed high rates of respiratory distress syndrome in neonates born to mothers with intrahepatic cholestasis of pregnancy. Conclusion. The study revealed that intrahepatic cholestasis of pregnancy has adverse impact on perinatal outcomes, showed rising rates of preterm birth, neonatal respiratory distress syndrome and cesarean section. This correlates with the data in the published scientific literature.
Full Text
About the authors
M. I Chemortan
Nicolae Testemianu Moldova State University of Medicine and Pharmacy (USMF)
Email: maria.cemortan@usmf.md
PhD student bd. §tefan cel Mare §i Sfant, 165, mun. Chisinau, MD-2004, Moldova
I. V Sagaidak
Nicolae Testemianu Moldova State University of Medicine and Pharmacy (USMF)
Email: irina.sagaidac@usmf.md
university аssistant, PhD bd. §tefan cel Mare §i Sfant, 165, mun. Chisinau, MD-2004, Moldova
References
- Williamson C., Geenes V. Intrahepatic cholestasis of pregnancy. Obstet. Gynecol. 2014; 124(1): 120-33. https://dx.doi.org/10.1097/A0G.0000000000000346.
- Stulic M., Culafic D., Boricic I., Stojkovic Lalosevic M., Pejic N., Jankovic G. et al. Intrahepatic cholestasis of pregnancy: A case study of the rare onset in the first trimester. Medicina (Kaunas). 2019; 55(8): 454. https://dx.doi.org/10.3390/ medicina55080454.
- Smith D.D., Rood K.M. Intrahepatic cholestasis of pregnancy. Clin. Obstet. Gynecol. 2020; 63(1): 134-51. https://dx.doi.org/10.1097/ GRF.0000000000000495.
- Manzotti C., Casazza G., Stimac T., Nikolova D., Gluud C. Total serum bile acids or serum bile acid profile, or both, for the diagnosis of intrahepatic cholestasis of pregnancy. Cochrane Database Syst. Rev. 2019; (7): CD012546. https:// dx.doi.org/10.1002/14651858.CD012546.pub2.
- Hamalainen S.T., Turunen K., Mattila K.J., Kosunen E., Sumanen M. Long-term survival after intrahepatic cholestasis of pregnancy: A follow-up of 571 mothers. Eur. J. Obstet. Gynecol. Reprod. Biol. 2019; 240: 109-12. https://dx.doi. org/10.1016/j.ejogrb.2019.06.008.
- Успенская Ю.Б., Кузнецова И.В., Шептулин А.А. Сложности дифференциальной диагностики внутри печеночного холестаза беремкенных. Медицинский алфавит. 2018; 3(22): 51.
- Westbrook R.H., Dusheiko G., Williamson C. Pregnancy and liver disease. J. Hepatol. 2016; 64(4): 933-45. https://dx.doi.org/10.1016/j.jhep.2015.11.030.
- Glantz A., Marschall H.U., Mattsson L.A. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology. 2004; 40(2): 467-74. https://dx.doi.org/10.1002/hep.20336.
- Royal College of Obstetricians and Gynaecologists. Obstetric cholestasis. Green-top guideline no. 43. 2011. Available at: http://www.rcog.org.uk/files/ rcog-corp/GTG43obstetriccholestasis.pdf
- Palmer K.R., Xiaohua L., Mol B.W. Management of intrahepatic cholestasis in pregnancy. Lancet. 2019; 393(10174): 853-4. https://dx.doi.org/10.1016/ S0140-6736(18)32323-7.
- Geenes V., Williamson C., Chappell L.C. Intrahepatic cholestasis of pregnancy. Obstetrician Gynaecol. 2016; 18(4): 273-81. https://dx.doi.org/10.1111/ tog.12308.
- Вороник Ю.Н., Мацюк Я.Р. Холестаз беременных: тиопатогенез, лечение и прогноз (обзор). Вестник Смоленской государственной медицинской академии. 2018; 17(3): 75-82
- Medda S., Sengupta S, Palo U. A study of the outcome of pregnancy complicated by obstetric cholestasis. Int. J. Reprod. Contracept. Obstet. Gynecol. 2018; 7(3): 996-1001. https://dx.doi.org/10.18203/2320-1770.ijrcog20180880.
- Mohan M, Antonios A, Konje J., Lindow S., Ahmed Syed M., Akobeng A. Stillbirth and associated perinatal outcomes in obstetric cholestasis: a systematic review and meta-analysis of observational studies. Eur. J. Obstet. Gynecol. Reprod. Biol. 2019; 3: 100026. https://dx.doi.org/10.1016/j.eurox.2019.100026.
- Li L., Chen Y.H., Yang Y.Y., Cong L.E. ffect of intrahepatic cholestasis of pregnancy on neonatal birth weight: a meta-analysis. J. Clin. Res. Pediatr. Endocrinol. 2018; 10(1): 38-43. https://dx.doi.org/10.4274/jcrpe.4930.
- Arthuis C., Diguisto C., Lorphelin H., Dochez V., Simon E., Perrotin F. et al. Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study. PLoS One. 2020; 15(2): e0228213. https://dx.doi.org/10.1371/ journal.pone.0228213.
Supplementary files
