Use of donor gametes and embryos for the treatment of infertility


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Abstract

Objective. To evaluate the effectiveness of programs using donor gametes and embryos for the treatment of infertility by assisted reproductive technologies (ART). Materials and methods. The investigation used data on the effectiveness of ART cycles using donor sperm (DS), both fresh and cryopreserved donor oocytes (DOs, or donor embryos (DEs), including those after preimplantation genetic testing for aneuploidy (PGT-A). Results. Analysis of the effectiveness of 165 cycles with DS revealed a relationship of the effectiveness of programs using DS to a woman’s age. The analysis of that of299 cycles with DOs showed no significant differences in the programs using fresh and cryopreserved DOs. The results of 32 cycles with DEs suggest their high efficiency. Conclusion. The findings suggest that the use of donor gametes and embryos in the ART programs is highly effective in overcoming infertility. These programs used in accordance with clinical indications allow pregnancy to be achieved in patients who have significant restrictions on the use of their own gametes.

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About the authors

Natalia K. Bichevaya

International Center for Reproductive Medicine

Email: bichevaya@mcrm.ru
Head of the Laboratory of Assisted Reproductive Technologies

Olga A. Leontyeva

International Center for Reproductive Medicine

Email: olga_leont@mail.ru
Embryologist, Laboratory of Assisted Reproductive Technologies

Alsu F. Saifitdinova

International Center for Reproductive Medicine; A.I. Herzen Russian State Pedagogical University

Email: saifitdinova@mail.ru
Associate Professor, Department of Human and Animal Anatomy and Physiology; Deputy Head of the Laboratory of Assisted Reproductive Technologies

Yuliya R. Pastukhova

International Center for Reproductive Medicine

Email: yrpasr@mail.ru
Embryologist, Laboratory of Assisted Reproductive Technologies

Rena A. Kuznetsova

International Center for Reproductive Medicine

Email: kuznetsova@mcrm.ru
Embryologist, Laboratory of Assisted Reproductive Technologies

Elizaveta E. Nevskaya

International Center for Reproductive Medicine

Email: elizaveta.nevsk@yandex.ru
Embryologist, Laboratory of Assisted Reproductive Technologies

Igor V. Reshetnikov

International Center for Reproductive Medicine

Email: reshetnikov@mcrm.ru
PhD, Embryologist, Laboratory of Assisted Reproductive Technologies

Alisa N. Panina

International Center for Reproductive Medicine

Email: alisa@panina.net
Embryologist, Laboratory of Assisted Reproductive Technologies

Yanina A. Samoilovich

International Center for Reproductive Medicine

Email: yanasam@yandex.ru
Ph.D, obstetrician-gynecologist of Assisted Reproductive Technologies department

Olga B. Pashina

International Center for Reproductive Medicine

Email: olgap01@mail.ru
Biologist, Laboratory of Assisted Reproductive Technologies

Irina L. Puppo

International Center for Reproductive Medicine; V.A. Almazov National Medical Research Center

Email: il_trofimova@list.ru
Associate Professor, Department of Laboratory Medicine and Genetics

Elvira V. Isakova

International Center for Reproductive Medicine

Email: elvira@mcrm.ru
Ph.D. in Medical sciences, Head of Assisted Reproductive Technologies Department

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