Bisphenol A in infertile patients: impact on assisted reproductive technologies outcomes


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Abstract

Aim. To investigate the relationship between bisphenol A levels in infertile patients and the outcomes of assisted reproductive technologies (ART). Materials and methods. Three hundred one married couples underwent assisted reproductive technology treatment. Blood and follicular fluid (FF) levels of bisphenol A were determined by chromatography-mass spectrometry. The study analyzed the impact of bisphenol A level on early embryogenesis parameters and ART outcomes. Results. Bisphenol A was detected in 92.9% (277/298) of blood and 16.8% (49/292) of FFsamples. No statistical relationship was found between the blood and FF bisphenol levels in the same patients. There were no differences in main early embryogenesis parameters and pregnancy rates in the quartile subgroups of blood bisphenol A. When dividing patients into groups based on the presence or absence of a detectable (i.e., 0.1 ng/ml and higher) bisphenol A in FF, no statistically significant differences in embryological parameters were revealed. Among 48 patients with available bisphenol A data both in the blood and FF, 24 had higher FF bisphenol A levels, and in the other 24 patients, it was higher in the blood. Patients with bisphenol A levels in FF higher than that in the blood had decreased number and quality of oocytes and embryos. Conclusion. Increased level of bisphenol A in FF compared with its level in the blood is associated with a decrease in the number and quality of oocytes in ART.

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About the authors

A. G Syrkasheva

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a_syrkasheva@oparina4.ru
Ph.D., Senior Researcher at the B.V. Leonov Department of Assisted Technologies for the Treatment of Infertility 117997, Russia, Moscow, st. Academician Oparin, 4

S. V Kindysheva

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: s_kindysheva@oparina4.ru
Ph.D., Senior Researcher at the Laboratory of Proteomics and Metabolomics of Human Reproduction, Department of Systems Biology in Reproduction 117997, Russia, Moscow, st. Academician Oparin, 4

N. L Starodubtseva

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: n_starodubtseva@oparina4.ru
Ph.D. (biol.sci.), Head of the Laboratory of Proteomics and Metabolomics of Human Reproduction, Department of Systems Biology in Reproduction 117997, Russia, Moscow, st. Academician Oparin, 4

V. E Frankevich

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: v_frankevich@oparina4.ru
Ph.D. (Physical and Mathematical Sciences), Head of the Department of Systems Biology in Reproduction 117997, Russia, Moscow, st. Academician Oparin, 4

N. V Dolgushina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
Dr. Med. Sci., Deputy Director - Head of the Department of Research Administration 117997, Russia, Moscow, st. Academician Oparin, 4

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