CARBOHYDRATE AND LIPID METABOLISM AND OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH MENSTRUAL IRREGULARITIES AND OBESITY


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Abstract

Aim. To investigate the association between oxidative stress and metabolic parameters in patients with obesity and menstrual irregularities. Materials and methods. The study included 24 obese women aged 20-35 years with menstrual irregularities (study group) and 15 obese women with regular menstrual cycles (control group). Results. Body mass index ranged from 30.8 to 41.2 and from 29.7 to 40.9 kg/m2 in the study and control group patients, respectively. Study group patients had statistically significantly higher serum VLDL-C concentration. There were small but statistically significant differences between the study and control groups in the concentration of malondialdehyde [2.8 nmol/ml (0.56; 3.7) vs 1.5 nmol/ml (0.43; 2.1)]. Study group patients with PCOS had statistically significantly higher concentrations of malondialdehyde [3.5 (2.4; 3.9) nmol/ml], and 8-OH-deoxyguanosine [0.36 (0.25; 0.44) ng/ml] than control subjects. Fasting and post-load insulin concentrations, serum concentrations of VLDL-C, LDL-C, SHBG, and free testosterone were statistically significantly higher in patients with PCOS than in control subjects. Conclusion. Patients with menstrual irregularities and obesity had higher levels of metabolic and antioxidant defense abnormalities than women with obesity and a regular menstrual cycle. These differences were even more pronounced in women with PCOS.

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About the authors

Olga L. GLAZKOVA

Russian Medical Academy of Continuing Postgraduate Education, Ministry of Health of Russia

Email: glazkova-ol-le@yandex.ru
Ph.D., Associate Professor at the Department of Obstetrics and Gynecology Moscow, Russia

Svetlana V. SHMELEVA

K.G. Razumovsky Moscow State University of Technologies and Management (FCU)

Email: 89151479832@mail.ru
Dr. Med. Sci., Professor Moscow, Russia

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