Autologous platelet rich plasma in complex therapy of women with refractory ‘‘thin’’ endometrium


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Abstract

Materials and methods. The research enrolled 68 patients of reproductive age with "thin" endometrium, refractory to e standard therapy, implantation failures and the history of ET cycle cancellation. Patients from the main group (n=38) first received physical therapy starting from day 5-7 of the menstrual cycle within 10 days. During the next menstrual cycle they received 35-40 ml of autologous PRP injections to the endometrium by hysteroscopy with use of endoscopic needle. Patients from the control group (n=30) were treated using only physical therapy. During the possible “implantation window” prior to and after the therapy endometrium thickness and hemodynamics of the uterine arteries were assessed. Results. Control ultrasound scan documented statistically significant endometrium thickness enlargement during the “implantation window” (p<0,001) in the patients of the main group comparing to those from the control group. According to Doppler velocimetry, this finding was associated with the improvement of uterine hemodynamics measurements. No adverse and allergic reactions, as well as infectious complications were registered after the interventions. Conclusion. The study demonstrated the effectiveness of a new approach to the complex therapy of women suffering from infertility associated with refractory “thin” endometrium and decreased of uterine arteries hemodynamics.

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About the authors

Inna A. Apolikhina

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: i_apolikhina@oparina4.ru
MD, Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation; Professor of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education

Zulfiya N. Efendieva

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: efendievaz@yandex.ru
postgraduate fellow at the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education

Tatiana A. Fedorova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: t_fyodorova@oparina4.ru
MD, Professor, Head of the Department of Transfusiology

Dmitrii M. Belousov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: slides@narod.ru
PhD, Clinical Head of Ultrasound and Functional Diagnostics Department, echography expert

Polina A. Vishnyakova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: p_vishnyakova@oparina4.ru
PhD, senior researcher, Laboratory of Regenerative Medicine

Daria A. Artemova

Scientific Research Institute of Human Morphology

Email: artiomova.darya@yandex.ru
junior researcher, Laboratory of Growth and Decision

Timur Kh. Fatkhudinov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; Scientific Research Institute of Human Morphology

Email: tfat@yandex.ru
PhD, MD, leading researcher, Laboratory of Regenerative Medicine

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