The expression level of long non-coding RNAs ROR and MALAT1 in endometriosis


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Abstract

Objective. To estimate the expression level of long non-coding RNAs ROR and MALAT1 in the endometriosis-affected ovarian tissue biopsy specimens relative to the control group. Materials and methods. The endometrioid ovarian cyst and endometriosis-unaffected ovarian tissue samples from 20 reproductive-aged women were examined. The expression of long non-coding RNAs ROR and MALAT1 was analyzed by real-time PCR using primers that were specific to these genes. Results. There was a substantial decrease in the expression level of long non-coding RNA ROR and an increase in the expression of MALAT1 in the endometriosis-affected tissue samples relative to the control group. Conclusion. The investigation revealed a relationship between the decreased level of lncROR expression, the increased level of MALAT1, and the presence of ovarian endometriosis. The findings suggest that long non-coding RNAs play a possible role in the development of proliferative processes in ovarian endometriosis and correlate with the data obtained from the analysis of uterine myoma samples. Further investigations may determine the clinical potential of long non-coding RNAs in the diagnosis and treatment of proliferative diseases of the female reproductive system, in particular precancerous ovarian lesions.

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About the authors

S. A Levakov

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: levakoff@yandex.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology, Institute of Clinical Medicine named after N.V. Sklifosovsky 119991, Russia, Moscow, Trubetskaya str., 8-2

A. E Mamedova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: venesuela93@gmail.com
postgraduate student of the Department of Obstetrics and Gynecology, Institute of Clinical Medicine named after N.V. Sklifosovskiy 119991, Russia, Moscow, Trubetskaya str., 8-2

G. Ya Azadova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: gullyar.azadova@mail.ru
postgraduate student of the Department of Obstetrics and Gynecology, Institute of Clinical Medicine named after N.V. Sklifosovsky 119991, Russia, Moscow, Trubetskaya str., 8-2

S. V Paukov

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: spaukov@mail.ru
Ph.D., Associate Professor of the Department of Obstetrics and Gynecology, Institute of Clinical Medicine named after N.V. Sklifosovsky 119991, Russia, Moscow, Trubetskaya str., 8-2

M. I Maslyakova

National Research University «Higher School of Economics»

Email: marimasmari@gmail.com
student 101000, Russia, Moscow, Myasnitskaya str., 20

M. S Pavlyukov

Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: marat.pav@mail.com
Doctor of Biological Sciences, Senior Researcher of the Laboratory of Membrane and Bioenergetic Systems 117997, Russia, Moscow, Miklukho-Maklay str., 16/10

M. I Shakhparonov

Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Doctor of Chemistry, Leading Researcher of the Laboratory of Membrane and Bioenergetic Systems 117997, Russia, Moscow, Miklukho-Maklay str., 16/10

N. V Antipova

Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Ph.D., Senior Researcher of the Laboratory of Membrane and Bioenergetic Systems 117997, Russia, Moscow, Miklukho-Maklay str., 16/10

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