Resistant ovary syndrome and oocyte maturation in a test tube


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Abstract

Resistant ovarian syndrome (ROS) is a rare endocrine disease characterized by hypergonadotropic hypogonadism, primary or secondary amenorrhea, generally a normal number of ovarian antral follicles, resistance to endogenous and exogenous gonadotropins, a normal set of chromosomes, and correctly developed secondary sexual characteristics. Patients with this syndrome are included in the third group of the WHO classification of chronic anovulation. Infertility in these patients may be overcome with both donor programs and their own oocytes in assisted reproductive technology programs using in vitro maturation (IVM). This review presents the global experience with IVM technology leading to the birth of healthy babies in women with ROS.

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About the authors

Pavel P. Yakovlev

Next Generation Clinic

Email: iakovlevpp@gmail.com
PhD, obstetrician-gynecologist

Rostislav N. Kornilov

Next Generation Clinic

medical consultant

Marina N. Pavlova

Next Generation Clinic

Head of the embryological laboratory

Nikolay V. Kornilov

Next Generation Clinic

medical director, obstetrician-gynecologist

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