The follicular fluid metabolomic profile as a marker for oocyte quality in assisted reproductive technology programs


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Abstract

One of the leading factors in determining the success of assisted reproductive technologies is to obtain an embryo with a high implantation potential, which in turn depends more on the quality of gametes. The main criterion for assessing the quality of oocytes is their morphological characteristics. Recent studies are aimed at searching for more accurate and non-invasive markers that determine the egg ability to be fertilized and to subsequently develop to a normal embryo. Follicular fluid is a unique investigation object, as it carries information about the features of the metabolic activity of the oocyte, and hence its competence. A study of biological fluid metabolomes has become possible due to the technologies based on the use of mass spectrometry and nuclear magnetic resonance. This review presents studies that discuss whether the follicular fluid metabolomic profile can be investigated to assess the quality of an oocyte and the feasibility of using a number of metabolites as additional markers. It also gives the results of a number of studies of the complete metabolomic profile of follicular fluid from patients of different age groups and according to the values of anti-Mullerian hormone. There are data on the composition of follicular fluid in women with polycystic ovary syndrome and other metabolic disorders. The review describes the studies of follicular fluid metabolomes in patients with ovarian endometrioid cysts and in those with recurrent implantation failures. Conclusion: The results of the studies conducted have confirmed the prospects and relevance of further investigation of the follicular fluid metabolic profile, which may allow one to create predictive oocyte quality model in the future.

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About the authors

A. A Gaponenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: sasha.gap@mail.ru

E. V Mityurina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mity-elena@yandex.ru

V. E Frankevich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

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