Molecular markers for endometrial receptivity in assisted reproductive technology programs


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Abstract

Despite the increasing effectiveness of assisted reproductive technology (ART) programs, the frequency of successful embryo implantations remains low. The lack of implantation may be associated with impaired endometrial receptivity during the implantation window. To determine the receptivity of the endometrium, various diagnostic methods, such as histological analysis, electron microscopy, immunohistochemical examination, and molecular genetic analysis, have been developed and used; however, many of them depend on contributing factors and are of ow functional significance in solving this problem. The search for an ideal marker is now ongoing to determine the best moment for embryo transfer into the uterine cavity for an in vitro fertilization (IVF) cycle. The use of omix technologies to study the embryo culture medium could predict not only the quality, but also implantation potential of the embryo itself, as well as optimize the selection of embryos for transfer to the uterine cavity. However, to enhance the effectiveness of ART programs, it is advisable not only to study the embryonic profile, but also to assess endometrial receptivity. Conclusion: In this connection, analyzing the literature sources has shown that the study of the small non-coding RNA (sncRNA) in the endometrial samples is a promising and relevant analysis that will be able to personalize the approach to implementing ART programs.

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About the authors

Yael A. Gokhberg

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: dr.yaelgokhberg@gmail.com
postgraduate student at the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility

Angelika V. Timofeeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: avtimofeeva28@gmail.com
MD., Ph.D., Head of Laboratory of applied transcriptomics

Elena A. Kalinina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility

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