In vitro oocyte maturation


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Abstract

In vitro maturation (IVM) is an assisted reproductive technology (ART) that implies aspiration of immature oocytes and their subsequent in vitro maturation. This technology is of particular importance for patients with polycystic ovary syndrome, as it prevents a formidable complication, such as ovarian hyperstimulation syndrome, as well as for those with resistant syndrome of the ovaries that are unresponsive to gonadotropin stimulation, and for those with cancers due to the possibility to completely abandon any stimulation. Nevertheless, IVM ranks below classical in vitro fertilization (IVF) in efficiency. To enhance the latter of classical IVM, an innovative embryological procedure, a two-stage capacitation in vitro maturation (CAPA-IVM) system that includes a preparatory (pre-IVM) step, has been developed, which contributes to the acquisition of competence by oocytes, and their further cultivation and maturation in the IVM media. This technology has shown to be effective, but it has a rather limited application and at this stage requires further investigation. Conclusion: This literature review describes the experience and efficiency of IVM and CAPA-IVM procedures including those in comparison with classical IVF in different categories of patients on the basis of Russian and international publications on this topic from the Pubmed system. The choice of the optimal treatment policy for such patients also requires further investigation.

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About the authors

Nina D. Mikhailova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

graduate student of 1st Gynecology Department

Nona G. Mishieva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nondoc555@mail.ru
PhD, Senior Researcher of 1st Gynecology Department

Anastasia O. Kirillova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

PhD, Senior Researcher of 1st Gynecology Department

Bella A. Martazanova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bellamart88@mail.ru
PhD, Junior Researcher of 1st Gynecology Department

Lana G. Dzhincharadze

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

graduate student of 1st Gynecology Department

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