The place of alternative therapy in the algorithms for managing patients with climacteric syndrome in the context of personalized medicine

Many women experience various climacteric manifestations. Despite the fact that menopausal hormone therapy is the gold standard for relieving hot flushes, as many as 80% of patients have used at least one alternative method in an effort to alleviate their condition. It is today known that vasomotor symptoms are a serious risk factor for cardiovascular diseases, such as coronary heart disease, hypertension, and hyperlipidemia. It is the cardiovascular mortality that holds the lead in women; therefore, therapeutic measures aimed at relieving menopausal syndrome become not only the struggle for their quality of life, but also for a reduction in all-cause mortality. This topic is especially relevant for patients with contraindications to estrogen therapy, which forces physicians to look at evidence-based medicine for a safe treatment that is adequate to the severity of manifestations. The paper provides an overview of the current drug and non-drug methods that can relieve climacteric syndrome, by evaluating their efficiency and safety: exercises, diet therapy, psychological procedures, herbal remedies, amino acids, antidepressants (selective serotonin reuptake inhibitors), gabapentin, and neurokinin-3 receptor antagonists. Conclusion: Thus, the modern possibilities of alternative therapy allow a physician and a patient to sufficiently widely and adequately choose drugs on the requests of a woman so that she can go through the menopausal transition comfortably and safely, by maintain her quality of life.

menopause, climacteric syndrome, hot flushes, alternative therapy, beta-alanine