Possibilities for increasing the effectiveness of assisted reproductive technology programs using cumulus-oocyte complex-induced sperm selection


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Abstract

The data available in modern scientific literature on the role of cumulus cells and sperm selection using cumulus-oocyte complexes to improve the effectiveness of assisted reproductive technology (ART) programs were systematically analyzed. The review includes data from foreign articles found in the PubMed (https://pubmed. ncbi.nlm.nih.gov), which have been published over the past 10years. The cumulus cells surrounding the oocyte during natural fertilization serve as a selective barrier that allows the selection of spermatozoa with a high potential for penetration through the oocyte membranes (zona pellucida, membrane) and with the subsequent activation of a female germ cell. The review presents modern techniques that can simulate natural fertilization in infertility treatment programs using ART methods. It describes the impact of sperm selection technology using the cumulus cells on the fertility rates of male gametes and the results of in vitro fertilization programs. The review notes the contradictory results of the effectiveness of this selection on the outcomes of ART programs, which, according to some authors, depend on the manipulations and methods for preparing plates for sperm selection and on the quality of the cumulus cells derived from the spouse. Conclusion: The data accumulated to date confirm the feasibility and prospects of studying the effectiveness of various modern sperm selection techniques. Further studies are needed to assess the predictive value of the interaction of spermatozoa with cumulus cells on the effectiveness of ART programs and pregnancy outcomes. Further studies are needed to assess the predictive value of the sperm-cumulus cell interaction on the effectiveness of ART programs and pregnancy outcomes.

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About the authors

Alina V. Chistyakova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: alinadubinina_07@mail.ru
PhD Student, Department of IVF named after Professor BV. Leonov

Natalya P. Makarova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru
Dr. Bio. Sci., Leading Researcher, Department of IVF named after Professor BV. Leonov

Natalia N. Lobanova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_lobanova@oparina4.ru
Junior Researcher, Department of IVF named after Professor BV. Leonov

Veronika Yu. Smolnikova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_smolnikova@oparina4.ru
Dr. Med. Sci., Associate Professor, Leading Researcher, Department of IVF named after Professor BV. Leonov

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