EXPERIENCE WITH GINGER IN THE TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background: Nausea and vomiting of pregnancy are the most common symptoms of progressive gestation and occur in 70-80% of pregnant women. Nausea and vomiting of pregnancy are associated with certain adverse outcomes for the mother, fetus, and offspring, whereas their level has a significant negative impact on different aspects of women's quality of life, including working capacity, family relationships, - the ability to lead a usual social life and the willingness to become pregnant again. Objective: To study the efficacy of ginger extract in nausea and vomiting of pregnancy. Materials and methods: The observational study included 94 women at 6 to 16 weeks’ gestation with mild to moderate nausea and/or vomiting of pregnancy. The patients’ quality of life and health were assessed in a questionnaire before, during, and after the end of a treatment cycle, by determining the socioeconomic status, habits, and lifestyle from the Sickness Impact Prof ile questionnaire and the severity of nausea and vomiting of pregnancy from the Pregnancy-Unique Quantification of Emesis and Nausea. The efficacy of the Preginor complex for nausea and vomiting of pregnancy was evaluated at the end of the cycle of its administration and compared with the baseline values. Results: By the end of therapy with the complex, 37.2% of patients did not complain of nausea and vomiting and they did not require further administration of Preginor. Nausea and vomiting were assigned as mild in 55.3% of pregnant women. Only 7.5% of the women who participated in the study did not report any considerable positive changes in their health when taking the complex; they continued to have moderate nausea and vomiting with a lower symptom intensity, which improved the pregnant women’s general condition and quality of life. However, the number of these patients declined 4-fold. There was a 2.2-fold decrease in the mean total index of nausea and vomiting after a treatment cycle. Conclusion: The intake of the non-pharmacological complex Preginor substantially relieves the symptoms of nausea and vomiting and improves their quality of life. In our opinion, the use of Preginor as a dietary supplement is promising and causes its wider clinical introduction.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Sergey KHABAROV

Tula State University; Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of Russia»; VITROMED LLC

Email: s.v.habarov@mail.ru
Dr. Med. Sci., Merited Doctor of the Russian Federation, Associate Professor, Professor at the Department of Obstetrics and Gynecology, Medical Institute, Tula State University; Professor at the Department of Clinical Laboratory Diagnostics and Pathological Anatomy, Academy of Postgraduate Education of the FMBA Tula, Russia; Moscow, Russia

Әдебиет тізімі

  1. Liu C., Zhao G., Qiao D., Wang L., He Y., Zhao M. et al. Emerging progress in nausea and vomiting of pregnancy and hyperemesis gravidarum: challenges and opportunities. Front. Med. (Lausanne). 2022; 8: 809270. https://dx.doi.org/10.3389/fmed.2021.809270.
  2. Hu Y., Amoah A.N., Zhang H., Fu R., Qiu Y., Cao Y. et al. Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis. J. Matern. Fetal Neonatal Med. 2022 ; 35(1): 187-96. https://dx.doi.org/10.1080/14767058.2020.1712714.
  3. Wang H., Rolls E.T., Du X., Du J., Yang D., Li J. et al. Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children. BMC Med. 2020; 18(1): 228. https://dx.doi.org/10.1186/s12916-020-01701-y.
  4. Fiaschi L., Nelson-Piercy C., Deb S., King R., Tata L.J. Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population-based study. BJOG. 2019; 126(10): 1201-11. https://dx.doi.org/10.1111/1471-0528.15662.
  5. Koren G., Boskovic R., Hard M., Maltepe C., Navioz Y., Einarson A. Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy. Am. J. Obstet. Gynecol. 2002; 186(5, Suppl. Understanding): S228-31. https://dx.doi.org/10.1067/mob.2002.123054.
  6. Lacasse A., Rey E., Ferreira E., Morin C., Bérard A. Validity of a modified pregnancy-unique quantification of emesis and nausea (PUQE) scoring index to assess severity of nausea and vomiting of pregnancy. Am. J. Obstet. Gynecol. 2008; 198(1): 71.e1-7. https://dx.doi.org/10.1016/j.ajog.2007.05.051.
  7. Hada A., Minatani M., Wakamatsu M., Koren G., Kitamura T. The pregnancy-unique quantification of emesis and nausea (PUQE-24): configural, measurement, and structural invariance between nulliparas and multiparas and across two measurement time points. Healthcare (Basel). 2021; 9(11): 1553. https://dx.doi.org/10.3390/healthcare9111553.
  8. Nausea and Vomiting of Pregnancy. The American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 189. January 2018.Committee on practice bulletins-obstetrics. Obstet. Gynecol. 2018; 131(1): e15-30.
  9. Sarecka-Hujar B., Szulc-Musiol B. Herbal medicines-are they effective and safe during pregnancy? Pharmaceutics. 2022; 14(1): 171. https://dx.doi.org/10.3390/pharmaceutics14010171.
  10. Слизовский Г.В., Кужеливский И.И., Шикунова Я.В., Сигарева Ю.А. Опыт лечения раннего токсикоза беременных. Акушерство и гинекология. 2018; 10: 118-22. https://dx.doi.org/10.18565/aig.2018.10.118-122.
  11. Mao Q.Q., Xu X.Y., Cao S.Y., Gan R.Y., Corke H., Beta T., Li H.B. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods. 2019; 8(6): 185. https://dx.doi.ois/10.3390/foods8060185.
  12. Anh N.H., Kim S.J., Long N.P., Min J.E., Yoon Y.C., Lee E.G. et al. Ginger on human health: A comprehensive systematic review of 109 randomized controlled trials. Nutrients. 2020; 12(1): 157. https://dx.doi.org/10.3390/nu12010157.
  13. Zhang M., Zhao R., Wang D., Wang L., Zhang Q., Wei. S. et al. Ginger (Zingiber officinale Rosc.) and its bioactive components are potential resources for health beneficial agents. Phytother. Res. 2021; 35(2): 711-42. https://dx.doi.org/10.1002/ptr.6858.
  14. Kousch A. Ginger. In: Miller J.P., Van Buiten C., eds. Superfoods. Food and health. Springer; 2022: 97-108. https://dx.doi.org/10.1007/978-3-030-93240-4_8.
  15. Токарева С.В., Хадарцев А.А. Энтеросорбция как метод лечения интоксикации и серотониновой недостаточности (краткий обзор отечественной литературы). Вестник новых медицинских технологий. Электронное издание. 2021; 15(3): Публикация 3-1. https://dx.doi.org/10.24412/2075-4094-2021-3-3-1. Available at: http://www.medtsu.tula.ru/VNMT/Bulletin/E2021-3/3-1.pdf Дата обращения 14.05.2021.
  16. Royal College of Obstetricians and Gynaecologists. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum. RCOG Green-top Guideline No. 69, June 2016. 27р.
  17. Campbell K., Rowe H., Azzam H., Lane C.A. The management of nausea and vomiting of pregnancy. J. Obstet. Gynaecol. Can. 2016; 38(12): 1127-37. https://dx.doi.org/10.1016/j.jogc.2016.08.009.
  18. Lowe S.A., Bowyer L., Beech A., Robinson H., Armstrong G., Marnoch C., Grzeskowiak L. Guideline for the management of nausea and vomiting in pregnancy and hyperemesis gravidarum. Society of Obstetric Medicine of Australia and New Zealand (SOMANZ). The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. 2019. 30р.
  19. Abbas A.M. Is ginger really effective for the treatment of the first trimester nausea and vomiting? J. Matern. Fetal Neonatal Med. 2019; 32(10): 1748. https://dx.doi.org/10.1080/14767058.2017.1416082.
  20. Stanisiere J., Mousset P.Y., Lafay S. How safe is ginger rhizome for decreasing nausea and vomiting in women during early pregnancy? Foods. 2018; 7(4): 50. https://dx.doi.org/10.3390/foods7040050.
  21. Nurmi M., Rautava P., Gissler M., Vahlberg T., Polo-Kantola P. Recurrence patterns of hyperemesis gravidarum. Am. J. Obstet. Gynecol. 2018; 219(5): 469. e1-469.e10. https://dx.doi.org/10.1016/j.ajog.2018.08.018.
  22. Laitinen L., Nurmi M., Ellilä P., Rautava P., Koivisto M., Polo-Kantola P. Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives. Arch. Gynecol. Obstet. 2020; 302(4): 947-55. https://dx.doi.org/10.1007/s00404-020-05683-3.
  23. Berrak Mizrak Sahin. Investigation of factors associated with nausea and vomiting in pregnant women. J. Health Sci. Med. 2021; 4(4): 457-61. https://dx.doi.org/10.32322/jhsm.924353.
  24. Zhang H., Wu S., Feng J., Liu Z. Risk factors of prolonged nausea and vomiting during pregnancy. Risk Manag. Healthc Policy. 2020; 13: 2645-54. https://dx.doi.org/10.2147/RMHP.S273791.
  25. Bazargani F., Iliadis S.I., Elenis E. Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden. Sci. Rep. 2021; 11(1): 9039. https://dx.doi.org/10.1038/s41598-021-88575-z.
  26. Громова О.А., Торшин И.Ю., Тетруашвили Н.К., Лиманова О.А. О новых тенденциях в нутрициальной поддержке беременности. Акушерство и гинекология. 2018; 1: 21-8. https://dx.doi.org/10.18565/aig.2018.1.21-28.
  27. Дубровина С.О., Красильникова Л.В. Особенности диеты беременных. Акушерство и гинекология. 2018; 1: 135-40. https://dx.doi.org/10.18565/aig.2018.L135-140.
  28. Хабаров С.В., Денисова О.В. Гормоны репродуктивной оси: лабораторные методы оценки. Часть 2. Клиническая лабораторная диагностика: учебное пособие. Колмогоров И.А. (Новый формат). 2021. 123с.
  29. Choi H.J., Bae Y.J., Choi J.S., Ahn H.K., An H.S., Hong D.S. et al. Evaluation of nausea and vomiting in pregnancy using the Pregnancy-Unique Quantification of Emesis and Nausea scale in Korea. Obstet. Gynecol. Sci. 2018; 61(1): 30-7. https://dx.doi.org/10.5468/ogs.2018.61.L30.
  30. Хамошина М.Б., Епишкина-Минина А.А., Тулупова М.С., Яцышина Д.В. Тошнота и рвота беременных: стоит ли вмешиваться? StatusPraesens. Гинекология, акушерство, бесплодный брак. 2021; 4: 86-91.
  31. Heitmann K., Nordeng H., Havnen G.C., Solheimsnes A., Holst L. The burden of nausea and vomiting during pregnancy: severe impacts on quality of life, daily life functioning and willingness to become pregnant again - results from a cross-sectional study. BMC Pregnancy Childbirth. 2017; 17: 75. https://dx.doi.org/10.1186/s12884-017-1249-0.
  32. Iliadis S.I., Axfors C., Johansson S., Skalkidou A., Mulic-Lutvica A. Women with prolonged nausea in pregnancy have increased risk for depressive symptoms postpartum. Sci. Rep. 2018; 8(1): 15796. https://dx.doi.org/10.1038/s41598-018-33197-1.
  33. van Gelder M.M.H.J., Nordeng H. Antiemetic prescription fills in pregnancy: A drug utilization study among 762,437 pregnancies in Norway. Clin. Epidemiol. 2021; 13: 161-74. https://dx.doi.org/10.2147/CLEP.S287892.
  34. Smith J.A., Fox K.A, Clark Shannon M. Nausea and vomiting of pregnancy: treatment and outcome. Literature review current through; Apr 2022.
  35. Прегинор. Единый реестр свидетельств о государственной регистрации. Available at: https://portal.eaeunion.org/sites/odata/_layouts/15/portal.eec.registry.ui/directoryform.aspx?listid=0e3ead06-5475-466a-a340-6f69c01b5687&itemid=231#f=%D0%BF%D1%80%D0%B5%D0%B3%D0%B8%D0%BD%D0%BE%D1%80

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>