INCIDENCE OF ENDOMETRIAL HYPERPLASTIC PROCESSES IN INFERTILE WOMEN TREATED WITH IN VITRO FERTILIZATION


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective: To clarify the frequency and pattern of intrauterine pathology in a non-selective cohort of patients participating in assisted reproductive technologies (ART) programs. Materials and methods: The frequency of intrauterine pathology was explored in 973patients aged 23 to 44 years who had participated in ART programs. The diagnosis was finally verified with office or routine hysteroscopy and histomorphological examination. The incidence of endometrial hyperplastic processes (EHPs) in assessing its relationship to the use of previous treatment with ART was determined separately in groups of patients younger and older than 35 years. Results: Intrauterine pathology was found in 38% of all the patients involved in ART programs. In patients with initially suspected uterine factor infertility, its frequency increased up to 68%. The pattern of verified intrauterine pathology predominated with EHPs, accounting for 44%. Conclusion: In the non-selective population of patients participating in ART programs, the women with intrauterine pathology showed a preponderance of EHPs in its pattern, which manifested themselves as glandular hyperplasia and endometrial polyps.

Full Text

Restricted Access

About the authors

Irina Yu. ERSHOVA

Moscow Regional Research Institute of Obstetrics and Gynecology; Reproductive Health Clinic "PRIOR CLINIC"

Email: i3236987@gmail.com
PhD, Researcher at the Department of Reproduction, Moscow Regional Research Institute of Obstetrics and Gynecology, obstetrician-gynecologist, PRIOR CLINIC Moscow, Russia

Ksenia V. KRASNOPOLSKAYA

Moscow Regional Research Institute of Obstetrics and Gynecology; Reproductive Health Clinic "PRIOR CLINIC"

Email: guzmoniiag@gmail.com
Corresponding Member of the RAS, Dr. Med. Sci., Professor, Head of the Department of Reproductology, Moscow Regional Research Institute of Obstetrics and Gynecology, Head of the Department of High Reproductive Technologies, obstetrician-gynecologist, PRIOR CLINIC Moscow, Russia

Mekan R. ORAZOV

RUDN University

Email: omekan@mail.ru
Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology with a Course of Perinatology Moscow, Russia

Anton A. FEDOROV

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: gyn_endoscopy@mail.ru
Dr. Med. Sci., Leading Researcher at the Endoscopyc Surgery Department Moscow, Russia

Lidiya V. SHOSTENKO

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: lidsonnn@gmail.com
obstetrician-gynecologist, postgraduate student at the Department of Reproduction Moscow, Russia

References

  1. Корсак В.С., Смирнова А.А., Шурыгина О.В. Регистр ВРТ Российской ассоциации репродукции человека. Отчет за 2018 год. Проблемы репродукции. 2021; 27(2): 6-20. https://dx.doi.org/10.17116/repro2021270216.
  2. Edwards R.G. Human implantation: the last barrier in assisted reproduction technologies? Reprod. Biomed. Online. 2006; 13(6): 887-904. https://dx.doi.org/10.1016/s1472-6483(10)61039-5.
  3. Lessey B.A., Young S.A. What exactly is endometrial receptivity? Fertil. Steril. 2019; 111(4): 611-7. https://dx.doi.org/10.1016/j.fertnstert.2019.02.009.
  4. Munro M.G. Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity. Fertil. Steril. 2019; 111(4): 629-40. https://dx.doi.org/10.1016/j.fertnstert.2019.02.008.
  5. Paulson R.J.Introduction: endometrial receptivity: evaluation, induction and inhibition. Fertil. Steril. 2019; 111(4): 609-10. https://dx.doi.org/10.1016/j.fertnstert.2019.02.029.
  6. Auclair M.H., Yong P.J., Salvador S., Thurston J., Colgan T.T., Sebastianelli A.J. Guideline No. 392 - classification and management of endometrial hyperplasia. J. Obstet. Gynaecol. Can. 2019; 41(12): 1789-800. https://dx.doi.org/10.1016/j.jogc.2019.03.025.
  7. Sanderson P.A., Critchley H.O., Williams A.R., Arends M.J., Saunders PT. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum. Reprod. Update. 2017; 23(2): 232-54. https://dx.doi.org/10.1093/humupd/dmw042.
  8. Tian Y., Liu Y., Wang G., Yonghuan Lv., Zhang J., Bai X. et al. Endometrial hyperplasia in infertile women undergoing IVF/ICSI: A retrospective crosssectional study. J. Gynecol. Obstet. Hum. Reprod. 2020; 49(9): 101780. https://dx.doi.org/10.1016/j.jogoh.2020.101780.
  9. Стрижаков А.Н., Давыдов А.И., Пашков В.М., Лебедев В.А. Доброкачественные заболевания матки. М.: ГЭОТАР-Медиа; 2010.
  10. Савельева Г.М., Сухих Г.Т., Серов В.Н., Радзинский В.Е., Манухин И.Б., ред. Гинекология. Национальное руководство. М.: ГЭОТАР-Медиа; 2020.
  11. Ricci E., Moroni S., Parazzini F., Benzi G., Salerio B., Polverino G., La Vecchia A. Risk factors for endometrial hyperplasia: Results from a case-control study.Int. J. Gynecol. Cancer. 2002; 12(3): 257-60. https://dx.doi.org/10.1136/ijgc-00009577-200205000-00004.
  12. Краснопольская К.В., Назаренко Т.А. Клинические аспекты лечения бесплодия в браке. Диагностические и терапевтические программы с использованием методов восстановления естественной фертильности и вспомогательных репродуктивных технологий. Руководство. М.: ГЭОТАР-Медиа; 2013.
  13. Hur C., Rehmer J., Flyckt R., Falcone T. Uterine factor infertility: A clinical review. Clin. Obstet. Gynecol. 2019; 62(2): 257-70. https://dx.doi.org/10.1097/GRF.0000000000000448.
  14. Gompel A. Progesterone and endometrial cancer. Best Pract. Res. Clin. Obstet. Gynaecol. 2020; 69: 95-107. https://dx.doi.org/10.1016/j.bpobgyn.2020.05.003.
  15. Tanos V., Berry K.E., Seikkula J., Abi Raad E., Stavroulis A., Sleiman Z. et al. The management of polyps in female reproductive organs.Int. J. Surg. 2017; 43: 7-16. https://dx.doi.org/10.1016/j.ijsu.2017.05.012.
  16. Vitale S.G., Haimovich S., Laganà A.S., Alonso L., Di Spiezio Sardo A., Carugno J. From the global community of hysteroscopy guidelines committee. Endometrial polyps. An evidence-based diagnosis and management guide. Eur. J. Obstet. Gynecol. Reprod. Biol. 2021; 260: 70-7. https://dx.doi.org/10.1016/j.ejogrb.2021.03.017.
  17. Chandra V., Kim J.J., Benbrook D.M., Dwivedi A., Rai R.J. Therapeutic options for management of endometrial hyperplasia. J. Gynecol. Oncol. 2016; 27(1): e8. https://dx.doi.org/10.3802/jgo.2016.27.e8.
  18. Chen Q., Zhang D., Wang S., Lang J.H., Chao X.P., Fan Q.B. A prospective, open-label, single-arm study to evaluate the efficacy of dydrogesterone in the treatment of endometrial polyps. Gynecol. Endocrinol. 2021; 37(2): 152. https://dx.doi.org/10.1080/09513590.2020.1840546.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies