EFFECTIVENESS OF COMBINED PRIMING IN A LATE REPRODUCTIVE AGE PATIENT WITH ANDROGEN DEFICIENCY IN THE ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAM


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Abstract

Background: Late reproductive age is accompanied by a diminished ovarian reserve and a poor ovarian response as a result of physiological maturation and ovarian failure, and is a difficult problem in achieving pregnancy with one's own genetic material. Folliculogenesis of the active reproductive period is associated with sufficient androgen concentrations, which has been repeatedly shown in a model of women with polycystic ovary syndrome. The choice of the optimal method of treating infertility in late reproductive age women with androgen deficiency in the assisted reproductive technology program is currently the most discussed issue. Case report: The paper describes a clinical case of using combined androgen priming and metabolic therapy to improve folliculogenesis and embryogenesis in the in vitro fertilization program - intracytoplasmic sperm injection in a late reproductive age patient with androgen deficiency. Conclusion: The combined approach to treating infertility in women of late reproductive age demonstrates a better clinical effect than to using androgen priming only.

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About the authors

Alla A. GAVISOVA

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: gavialla@yandex.ru
Ph.D., Leading Researcher at the 1st Gynecology Department Moscow, Russia

Marina A. SHEVTSOVA

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: marina_98l995@mail.ru
post-graduate student Moscow, Russia

Anna G. BURDULI

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: burdulianna@gmail.com
Ph.D., Senior Researcher at the Department of Assisted Reproductive Technologies in the Treatment of Infertility named after B.V. Leonov Moscow, Russia

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