Birth of a healthy baby in a patient with diminished ovarian reserve after intraovarian autologous platelet-rich plasma injection and an in vitro fertilization program
- Authors: Kulakova E.V.1, Kraevaya E.E.1, Makarova N.P.1, Kalinina E.A.1, Nazarenko T.A.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Issue: No 5 (2022)
- Pages: 157-161
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249602
- DOI: https://doi.org/10.18565/aig.2022.5.157-161
- ID: 249602
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Abstract
Background: Diminished ovarian reserve remains one of the most pressing problems in modern reproduction. The use of donor oocytes is an effective way of coping with infertility in patients with decreased ovarian function despite the serious psychological difficulties of this approach. There are presently different experimental methods approved by local ethics committees, which are aimed at improving ovarian function, one of which is the intraovarian injection of a patient’s own platelet-rich plasma (PRP). Case report: This paper describes a clinical case of a successful delivery in a patient with a diminished ovarian reserve and a double intraovarian PRP injection. A 34-year-old patient with diminished ovarian reserve who came to the B.V. Leonov Department of Assisted Technologies, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, for infertility treatment, where she received two intraovarian PRP injections, followed by assisted reproductive technologies, resulting in pregnancy and spontaneous delivery of a live full-term fetus. Conclusion: According to the data available in the literature and to the Department's own accumulated experience in 61 patients, the intraovarian PRP injection may have a short-term positive effect on the ovarian function of patients with diminished ovarian reserve. It is necessary to continue investigations in this area and to gain clinical experience
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About the authors
Elena V. Kulakova
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: e_kulakova@oparina4.ru
Ph.D., Senior Researcher at the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility
Elizaveta E. Kraevaya
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: e_kraevaya@oparina4.ru
Ph.D., Junior Researcher at the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility
Natalia P. Makarova
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: np_makarova@oparina4.ru
Dr. Biol. Sci., Senior Researcher at the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility
Elena A. Kalinina
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the BV. Leonov Department of Assisted Technologies for the Treatment of Infertility
Tatyana A. Nazarenko
Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: t_nazarenko@oparina4.ru
Dr. Med. Sci., Professor, Director of the Institute of Reproductive Medicine
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