Cell subpopulation composition and cytokine content in peripheral blood before spontaneous and induced labor
- Authors: Tysyachnyi O.V.1, Inviyaeva E.V.1, Vtorushina V.V.1, Krechetova L.V.1, Baev O.R.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
- Issue: No 1 (2023)
- Pages: 67-74
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/250063
- DOI: https://doi.org/10.18565/aig.2022.323
- ID: 250063
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Abstract
According to current concepts, immunological mechanisms play a fundamental role in the initiation of labor. The current literature lacks information related to the plasma cytokine content of pregnant women prior to spontaneous and induced labor. Studying the cytokine profile may contribute to the identification of its imbalance and determine prognostic criteria for failed labor preinduction. Objective: To investigate cell subpopulation composition and cytokine content in peripheral blood before spontaneous and induced labor. Materials and methods: A prospective pilot study included 30 healthy primiparous women who were divided into 3 groups. Control group (n=8) included women with early signs of labor; patients in group 1 (n=14) required one stage of labor preparation to develop labor activity; patients in group 2 (n=8) required two stages of preparation. Results: Women who required longer labor preparation had significantly higher TNF-a levels [2.9 (2.0;3.1) vs 2.9 (2.0;3.7) vs 5.4 (4.3;6.1) pg/ml in the control group, group 1 and group 2, respectively, p=0.025]. Conclusion: The highest level of TNF-a in women who required the second stage of labor preparation probably reflects slower cervical ripening.
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About the authors
Oleg V. Tysyachnyi
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: o_tysyachny@oparina4.ru
Ph.D., Researcher at the lst Maternity Department
Evgeniya V. Inviyaeva
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: e_inviyaeva@oparina4.ru
PhD (Bio), Senior Researcher at the Laboratory of Clinical Immunology
Valentina V. Vtorushina
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: v_vtorushina@oparina4.ru
Ph.D., doctor of laboratory and clinical diagnostics at the Laboratory of Clinical Immunology
Lubov V. Krechetova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: k_l_v_@mail.ru
Dr. Med. Sci., Head of the Laboratory of Clinical Immunology
Oleg R. Baev
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: o_baev@oparina4.ru
Dr. Med. Sci., Professor, Head of the 1st Maternity Department; Professor at the Department of Obstetrics, Gynecology, Perinatology and Reproductology
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