Epigenetic aspects of the pathogenesis of preeclampsia


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Preeclampsia is a serious pregnancy complication that is a leading cause of maternal and perinatal morbidity and mortality. Of great interest is the study of new approaches to preventing, predicting, and treating this syndrome; however, it is difficult without understanding the basics of pathogenesis. The paper considers modern ideas about the mechanisms of preeclampsia. Fundamental significance is attached to the activation of the immune system; the cells of both innate and adaptive immunity are assumed to play a key role. It is known that epigenetic mechanisms, such as DNA methylation and the action of non-coding RNAs (ncRNAs), regulate many genes, including those involved in inflammation and immune response, and can serve as prognostic biomarkers and therapeutic targets in preeclampsia. Conclusion: The study of etiopathogenesis can become the basis for revealing the mechanism of this pregnancy complication, which directly facilitates the search for new markers for the early diagnosis of preeclampsia.

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作者简介

Natalia Kan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
Professor, MD, PhD, Deputy Director of Science

Dzhamilia Mirzabekova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: jamilya1705@yandex.ru
graduate student

Victor Tyutyunnik

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
Professor, MD, PhD, Leading Researcher of Research and Development Service

Aleksey Krasnyi

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: alexred@list.ru
PhD, Head of the Cytology Laboratory

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