Features of neurogenesis in fetal growth restriction


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Abstract

The paper analyzes the current literature data on the role of neurogenesis and fetal programming in fetal growth restriction. It considers the mechanisms and scientific hypotheses that lead to structural changes in the central nervous system and to neuroregulatory disorders even in the intrauterine period with adverse consequences to the development of the nervous system and social cognitive functions. The paper discusses the role of potential proteins as markers for brain damage in fetal growth restriction. A change in fetal programming, in the direction of immunometabolic processes, and in the level of an inflammatory response is a cause of health impairment, vital cardiovascular and neuroendocrine diseases in the postnatal period of life. Therefore, the identification of cellular and molecular mechanisms that cause placental dysfunction, the optimal development of fetal organs, and the disruption of genetic/epigenetic programming, proteins as markers for fetal brain matter damage, the determination of which is necessary for the early diagnosis of hypoxic ischemic encephalopathy, is a serious problem that needs to be further studied. Conclusion: With the introduction of modern studies of epigenetic regulation, there is hope for the development of new methods to predict and diagnose fetal growth restriction, taking into account the findings on etiology and pathogenesis. Increasing information on the fetal programming of certain diseases in adults may be an important trigger to stop the progression of pathology.

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About the authors

Natalia E. Kan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
Professor, Dr. Med. Sci., Deputy Director for Science

Anastasia A. Leonova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: nastena27-03@mail.ru
postgraduate student

Victor L. Tyutyunnik

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
Professor, Dr. Med. Sci., Leading Researcher at the Research and Development Service

Zarine V. Khachatryan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: z.v.khachatryan@gmail.com
postgraduate student

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