Asymptomatic bacteriuria in pregnancy: a modern approach to therapy


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Abstract

Objective: To evaluate the efficiency of combination therapy for asymptomatic bacteriuria in pregnant women, its impact on pregnancy outcomes and the course of the perinatal period. Materials and methods: The clinical study involved 44 patients who had experienced an episode of asymptomatic bacteriuria in the first trimester of pregnancy. There were two equal groups: a study group of 22 women who received therapy with antibacterial and immunomodulatory drugs and a comparison group of 22 patients who had monotherapy with an antibacterial drug. The efficiency of different treatment regimens for asymptomatic bacteriuria was evaluated, by analyzing the results of laboratory tests, such as clinical urinalysis and urine microbiological examination; the duration of a relapse and an interval between exacerbations; and the course of labor and perinatal outcomes. Results: The patients treated with a combination of an antibacterial drug and an immunomodulatory agent for asymptomatic bacteriuria in pregnancy had the best therapy results. This was confirmed by a considerable reduction in the growth of pathogenic microorganisms during microbiological examination, a substantially longer interval between relapses, and a decrease in their duration. The study group showed the most favorable obstetric and perinatal outcomes. Conclusion: The immunomodulator Superlymph can be recommended for use in combination with an antibacterial drug in the treatment of asymptomatic bacteriuria in pregnant women. In the authors’ opinion, this combination is effective in achieve a high therapeutic effect.

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About the authors

Victor L. Tyutyunnik

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
Professor, Dr. Med. Sci., Leading Researcher at the Research and Development Service

Olga I. Mikhailova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: omikhaylova@gmail.com
PhD, Researcher, l Maternity Department

Natalia E. Kan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
Professor, Dr. Med. Sci., Deputy Director for Science

Dzhamilia D. Mirzabekova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: jamilyal705@yandex.ru
graduate student

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